Professor O'Brien (UCL and The Royal Free) used to run a laboratory group but was lucky enough to progress an idea from bench to trial and, even though it did not work, found he much preferred doing clinical trials in cirrhosis. He has been very fortunate to deliver the ATTIRE & ASEPTIC UK clinical trials and will shortly begin another, even larger trial, APEACH (The Apixaban to Prevent dEcompensation of eArly liver CirrHosis trial). Hopefully he will be able to do at least one or two more following this daunting task. Away from medicine, he is a committed father, husband and runner, but a terrible surfer.