Jessica H Hartman, PhD

Biography

Dr. Jessica Hartman is a tenure-track Assistant Professor in the Department of Biochemistry and Molecular Biology and the Department of Regenerative Medicine at the Medical University of South Carolina. Dr. Hartman completed her Ph.D. with the support of a NSF GRFP fellowship at the University of Arkansas for Medical Sciences in the lab of Dr. Grover Miller studying enzyme kinetics of substrate oxidation by cytochrome P450 2E1 (CYP2E1). She then went on to do a NIEHS F32-supported postdoctoral fellowship with Dr. Joel Meyer at the Nicholas School of the Environment at Duke University where she studied mitochondrial toxicity in Caenorhabditis elegans, with a special focus on dopaminergic neurotoxicity while continuing her work on CYP2E1. She was then awarded a K99/R00 Transition to Independence award from NIEHS to study dopaminergic neurotoxicity rescue by long-term exercise in C. elegans. Now the Hartman lab at MUSC studies how diet and exercise induce changes in metabolism, including through CYP2E1, and how this alters cellular stress and response to ethanol and toxic insults. Ongoing projects in the lab, supported by a R35 MIRA award from NIGMS and a R01 from NIAAA, focus on fundamental biochemical pathways within the liver-intestine-brain axis under normal conditions and during stress.