Sexual Dimorphism in the Liver

Description

Presenters review recent advances in our understanding of sexual dimorphism in the liver and its contribution to liver growth, metabolism, and disease. The concepts covered by the thought leaders and content experts include the effect of sex hormones on hepatocyte proliferation and sex-specific differences in metabolic demands. They also cover concepts of sexually dimorphic responses in specific chronic pathologies including MASLD and HCC. Sex as a biological variable is often overlooked, which can result in delayed or inappropriate treatment. However, because the liver responds differently in males and females, this important variable needs to be considered both in experimental design and interpretation.

Journey Maps

Presentations

2:00 PM - 2:15 PM
Nov 08 2025
Washington, D.C.

Sexual Dimorphism and Upstream Regulator of Pioneer Factors Foxa1 and Foxa2 in Physiology

Irina M Bochkis, PhD, Presenter
Basic Science
2:15 PM - 2:30 PM
Nov 08 2025
Washington, D.C.

Effect of Gender in Hepatocellular Carcinoma Progression

Chris Green, PhD, Presenter
Basic Science
2:30 PM - 2:45 PM
Nov 08 2025
Washington, D.C.

Sexual Dimorphism in Advanced Chronic Liver Disease

Jordi Gracia-Sancho, PhD, FAASLD, Presenter
Basic Science
2:45 PM - 3:00 PM
Nov 08 2025
Washington, D.C.

Role of Sex Hormones in Nuclear Receptor Signaling

Grace L Guo, MBBS, PhD, Presenter
Basic Science
3:00 PM - 3:15 PM
Nov 08 2025
Washington, D.C.

Impact of Estrogen on Regulation of Nuclear Receptors

Sayeepriyadarshini Anakk, PhD, Presenter
Basic Science

Objectives

  • Discuss the importance of studying sexual dimorphism in liver disease.
  • Describe recent advances in our understanding of sexual dimorphism in the liver and its effects on disease progression.
  • Explain the role of nuclear receptors in regulating differences in gene expression and disease severity between males and females.
Chair

Kari Nejak-Bowen, MBA, PhD

University of Pittsburgh
Chair

Wen-Xing Ding, MD, PhD, FAASLD

University of Kansas Medical Center