Grace L Guo, MBBS, PhD

Biography

Grace L. Guo, MBBS, PhD, FAASLD, is a professor in the Department of Pharmacology and Toxicology at the Ernest Mario School of Pharmacy in the Rutgers University. She received a MBBS degree from the West China University of Medical Science (Now the West China Medical Center of Sichuan University), and a PhD degree in Toxicology from the University of Kansa Medical Center. Her postdoctoral training was obtained from the NCI, NIH, with Dr. Frank Gonzalez. Dr. Guo has been a faculty in the University of Kansas Medical Center from 2004 to 2012 and in Rutgers University since 2012.

For the last three decades, Dr. Guo has dedicated her research career on the molecular mechanisms of regulation of drug metabolism, bile acid signaling and toxicology by nuclear receptors, including FXR, PXR and CAR. She made important discovery in determining the molecular mechanisms by which xenobiotic nuclear receptors regulate chemical disposition. She is one of the pioneer scientists discovering the importance of intestinal FXR and bile acid signaling in regulating liver functions and disease development. Her lab has made several genetically modified mouse models to advance the understanding of human physiology, pathology, pharmacology and toxicology. She has been funded by the NIH and the VA for the last 20 years, published about 160 peer-reviewed papers, editorial, and book chapters in pharmacology, toxicology and hepatology areas, mentored many students and fellows, and served on the NIH and VA study sections.

Dr. Guo has been involved in professional societies to advance the field of Hepatology, gastroentorology, toxicology, and drug metabolism. She received several national and university Awards for her contribution in investigting the gut-liver axis, inclduing the Inaugural Presidential Outstanding Faculty Scholar Award at the Rutgers University (2021). the James R. Gillette Drug Metabolism and Disposition Best Paper (2023), and the Division for Toxicology Career Award, ASPET (2024).