Liver Disease in People Living With Human Immunodeficiency Virus: Across the Continuum of Care

Liver disease remains one of the most important comorbidities affecting people living with HIV and continues to be a leading contributor to non–AIDS-related morbidity and mortality. While advances in antiretroviral therapy have transformed HIV into a chronic condition, the burden of liver disease has expanded beyond viral hepatitis to include metabolic dysfunction–associated steatotic liver disease (MASLD), alcohol-associated liver disease, and advanced cirrhosis. At the same time, HIV care has led the way in destigmatization, community engagement, and patient-centered research, generating care models that offer valuable lessons for longitudinal liver care. In the context of a rapidly evolving health care and policy landscape, these gains face new challenges that may affect access, continuity, and equity of liver-related services. This session examines HIV-related liver disease across the continuum of care, including progress and remaining gaps in viral hepatitis elimination; emerging nonviral drivers of liver disease; advances in liver transplantation in the HIV Organ Policy Equity (HOPE) Act era; and insights from HIV care models that can inform contemporary hepatology practice.