Metabolic Dysfunction–Associated Steatotic Liver Disease and Glucagon-like Peptide-1 Drugs: What Patients Want to Know

Nov 07 2026
Convention Center: Mile High Ballroom 4DEF
2:00 PM - 3:30 PM

Description

Glucagon-like peptide-1 (GLP-1) drugs—including both GLP-1 receptor agonists and dual GLP-1/glucose-dependent insulinotropic polypeptide [GIP] receptor agonists—have become ubiquitous in the public arena. These drugs represent some of the most promising treatment options for persons with metabolic dysfunction–associated steatohepatitis (MASH) because they treat the underlying comorbidities (obesity and diabetes) as well as MASH. Additionally, they have proven cardiovascular benefits. Persons with MASH want reliable information on whether they are eligible to be treated with GLP-1 drugs; what to expect in terms of response; how to monitor response; and how to manage potential side effects.   Key topics addressed by speakers include: Why GLP-1 drugs are showing such promise in metabolic dysfunction–associated steatotic liver disease (MASLD) Mechanism of liver benefit  Expected treatment response and variability Tolerability and side effect management Eligibility, nonresponse, and discontinuation

Presentations

2:00 PM - 2:20 PM
Convention Center - Mile High Ballroom 4DEF

Why Are Current and Pipeline GLP-1/GIP Therapies So Promising in Metabolic Dysfunction–Associated Steatotic Liver Disease Across the Disease Spectrum and How Do You Select and Counsel Patients for Treatment?

Rohit Loomba, MD, MHSc, FAASLD | Presenter
2:20 PM - 2:40 PM
Convention Center - Mile High Ballroom 4DEF

Patient Experiences of Treatment With Glucagon-like Peptide-1 Drugs for Metabolic Dysfunction–Associated Steatohepatitis

Kerry M. Sivia, B.A. | Presenter
2:40 PM - 3:00 PM
Convention Center - Mile High Ballroom 4DEF

Managing Patients After They Start Glucagon-like Peptide-1 Drug Treatment: Dosage, Side Effects, Response, and Discontinuation

Mary E. Rinella, MD, FAASLD | Presenter
3:00 PM - 3:20 PM
Convention Center - Mile High Ballroom 4DEF

Building a Coalition of Community Partners and Stakeholders to Address Treatment for Metabolic Dysfunction–Associated Steatotic Liver Disease

Sharon H Jaycox, PhD | Presenter

Objectives

  • Discuss why glucagon-like peptide-1 (GLP-1) drug therapies are showing such promise in metabolic dysfunctionassociated steatotic liver disease (MASLD), including whether potential liver benefit is thought to be direct or primarily related to weight loss.
  • Review expectations for treatment response, what meaningful improvement may look like over time, and variability in response to promote ongoing engagement in care.
  • Summarize GLP-1 drug tolerability, management of side effects (eg, nausea or muscle loss), and when to potentially stop treatment.
  • Describe what to do if a patient is ineligible for GLP-1 drug therapy or is not responding to treatment.