Molecular Mechanisms of Alcohol-Associated Liver Disease

This session explores the molecular and cellular mechanisms driving alcohol-associated liver disease. Presentations examine impaired lipophagy and lysosomal damage in hepatocellular steatosis, epigenetic remodeling of immune and inflammatory pathways, and novel approaches to targeting TNF-α signaling without systemic cytokine blockade. Additional talks reveal a circRNA axis governing sphingolipid dysregulation, an alcohol-induced bile acid intermediate modulating intestinal FXR-FGF15/19 signaling, and UBC9-driven transcriptional reprogramming in macrophage inflammatory activation. Together, these studies illuminate emerging pathways and potential therapeutic targets across lipid metabolism, epigenetics, inflammation, and the gut-liver axis.