Redefining Care for Acute-on-Chronic Liver Failure: Critical Illness, Organ Failures, and Global Consensus

Nov 07 2026
Convention Center: Bluebird Ballroom 1B
11:00 AM - 12:30 PM
Captured/recorded session Recorded
CE Credits CE Credits

World Class Speakers

Christina C Lindenmeyer

Chair
Christina C Lindenmeyer, MD,

Ruben Hernaez

Chair
Ruben Hernaez, MD, MPH, PhD

Christina C Lindenmeyer

Presenter
Christina C Lindenmeyer, MD,

Jasmohan S. Bajaj

Presenter
Jasmohan S. Bajaj, MD, FAASLD

Elizabeth C Verna

Presenter
Elizabeth C Verna, MD, MS, FAASLD

Ruben Hernaez

Presenter
Ruben Hernaez, MD, MPH, PhD

Joanna C Dionne

Presenter
Joanna C Dionne, MD, MS, PhD, FRCPC

Anand Kulkarni

Moderator
Anand Kulkarni, MD, , DM

Filipe S. Cardoso

Moderator
Filipe S. Cardoso, MD

Description

Acute-on-chronic liver failure (ACLF) represents one of the most challenging syndromes in hepatology and critical care, characterized by rapid deterioration, multiorgan failure, and high short-term mortality. This symposium explores cutting-edge strategies for managing critically-ill ACLF patients, standardizing organ failures, and translating global consensus into clinical practice. Topics include intensive care unit management, infection and immune dysfunction, post ACLF recovery, and practical implications of the 2026 European Association for the Study of the Liver Global ACLF Consensus Meeting. Presenters aim to provide actionable insights to improve outcomes and advance care for this vulnerable population.

Presentations

11:00 AM - 11:15 AM
Convention Center - Bluebird Ballroom 1B
Recorded session

Redefining Organ Failure in Acute-on-Chronic Liver Failure: Advancing Global Standards

Christina C Lindenmeyer, MD, | Presenter
11:15 AM - 11:30 AM
Convention Center - Bluebird Ballroom 1B
Recorded session

Critical Care Pathways for Acute-on-Chronic Liver Failure: High-Stakes Decisions in the Intensive Care Unit

Joanna C Dionne, MD, MS, PhD, FRCPC | Presenter
11:30 AM - 11:45 AM
Convention Center - Bluebird Ballroom 1B
Recorded session

Infection and Immune Dysfunction in Acute-on-Chronic Liver Failure: Breaking the Cycle of Sepsis

Jasmohan S. Bajaj, MD, FAASLD | Presenter
11:45 AM - 12:00 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Beyond the Intensive Care Unit: Life After Acute-on-Chronic Liver Failure

Elizabeth C Verna, MD, MS, FAASLD | Presenter
12:00 PM - 12:15 PM
Convention Center - Bluebird Ballroom 1B
Recorded session

Translating Global Consensus Into Practice: Shaping the Future of Acute-on-Chronic Liver Failure Care

Ruben Hernaez, MD, MPH, PhD | Presenter

Objectives

  • Link early critical-care decisions to downstream outcomesincluding survival, functional recovery, and post intensive care unit (ICU) quality of lifeand determine when acute-on-chronic liver failure (ACLF) consensus criteria should drive care versus when individualized clinical judgment, patient goals, and local resource considerations should take precedence.
  • Identify key changes in the 2026 Global ACLF Consensus. Explain how revised organ failure definitions modify ACLF classification and prognosis, and apply these definitions within a trajectorybased framework to guide ICU escalation, reassessment, and transplant decisionmaking.
  • Incorporate understanding of immune dysfunction into ACLF management decisions, recognizing its impact on infection vulnerability, organ failure progression, and responsiveness to therapies.

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