AASLD/EASL Endpoints for Clinical Trials: MetALD, ALD, MASLD, and Alpha-1 Antitrypsin Deficiency

Description

As the landscape of liver disease evolves, so too must our tools for evaluating therapeutic efficacy and disease progression.  This cutting-edge session will explore the latest advances and ongoing debates surrounding clinical trial and real-world endpoints for metabolic dysfunction-associated alcohol-related liver disease (MetALD), alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), and alpha-1 antitrypsin deficiency (AATD). For MetALD, we will present the consensus endpoints developed by the AASLD/EASL MetALD Working Groups.  Experts will address the challenges of defining meaningful and harmonized endpoints across overlapping phenotypes, the role of biomarkers and imaging, and regulatory considerations in early- and late-phase trials. Emphasis will be placed on how to tailor endpoints to the unique pathophysiology of each disease while also considering patient-centered outcomes and emerging surrogate markers. This session is essential for clinicians, researchers, and industry stakeholders involved in trial design and drug development for liver diseases. 

Presentations

8:00 AM - 8:05 AM
Nov 09 2025
Washington, D.C.

Welcome & Introductions

Grace Su, MD, FAASLD, Moderator
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:05 AM - 8:20 AM
Nov 09 2025
Washington, D.C.

General Considerations for Clinical Trials in MetALD/ALD

Aleksander A. Krag, MD, PhD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:20 AM - 8:35 AM
Nov 09 2025
Washington, D.C.

Endpoints for Phases 2 and 3 Trials in Precirrhotic MetALD/ALD

Mazen Noureddin, MD, MHSc, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:35 AM - 8:50 AM
Nov 09 2025
Washington, D.C.

Endpoints in Patients with Compensated Cirrhosis or Compensated Advanced Chronic Liver Disease (cACLD)

Juan Pablo Arab, MD, FRCPC, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:50 AM - 9:05 AM
Nov 09 2025
Washington, D.C.

Endpoints in Patients with Decompensated Cirrhosis

Debbie L Shawcross, BSc, MBBS, PhD, FRCP, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:05 AM - 9:25 AM
Nov 09 2025
Washington, D.C.

Panel Discussion 1 (All Presenters and FDA Speakers)

Grace Su, MD, FAASLD, Moderator
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:25 AM - 9:40 AM
Nov 09 2025
Washington, D.C.

Endpoints for Regulatory Approval in MASH-Related Fibrosis

Mary E. Rinella, MD, FAASLD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:40 AM - 9:55 AM
Nov 09 2025
Washington, D.C.

Endpoints for Regulatory Approval in Alcohol-associated Hepatitis

Gyongyi Szabo, MD, PhD, FAASLD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:55 AM - 10:10 AM
Nov 09 2025
Washington, D.C.

Endpoints for Regulatory Approval in Alpha-1 Anti-Trypsin Deficiency-Related Liver Disease

Rohit Loomba, MD, MHSc, FAASLD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
10:10 AM - 10:30 AM
Nov 09 2025
Washington, D.C.

Panel Discussion 2 (All Presenters and FDA Speakers)

Rotonya M. Carr, MD, FACP, FAASLD, Moderator
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
6:51 PM - 6:51 PM
Nov 09 2025
Washington, D.C.

Panel Discussion

Caroline C. Duwaerts, Ph.D., Panelist
Frank A Anania, MD, FAASLD, FACP, AGAF, Panelist
Ruby Mehta, MD, Panelist
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD

Objectives

  • identify current and emerging clinical and surrogate endpoints for MetALD, ALD, MASLD, and AATD.
  • Describe the regulatory pathways across a spectrum of chronic liver disease.
  • Discuss the future of personalized and mechanism-based endpoints in liver disease trials.