AASLD/EASL Endpoints for Clinical Trials: MetALD, ALD, MASLD, and Alpha-1 Antitrypsin Deficiency

Description

As the landscape of liver disease evolves, so too must our tools for evaluating therapeutic efficacy and disease progression.  This cutting-edge session will explore the latest advances and ongoing debates surrounding clinical trial and real-world endpoints for metabolic dysfunction-associated alcohol-related liver disease (MetALD), alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), and alpha-1 antitrypsin deficiency (AATD). For MetALD, we will present the consensus endpoints developed by the AASLD/EASL MetALD Working Groups.  Experts will address the challenges of defining meaningful and harmonized endpoints across overlapping phenotypes, the role of biomarkers and imaging, and regulatory considerations in early- and late-phase trials. Emphasis will be placed on how to tailor endpoints to the unique pathophysiology of each disease while also considering patient-centered outcomes and emerging surrogate markers. This session is essential for clinicians, researchers, and industry stakeholders involved in trial design and drug development for liver diseases. 

Presentations

8:00 AM - 8:05 AM
Nov 09 2025
Washington, D.C.

Welcome & Introductions

Grace Su, MD, FAASLD, Moderator
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:05 AM - 8:20 AM
Nov 09 2025
Washington, D.C.

General considerations for clinical trials in MetALD/ALD

Aleksander Krag, MD, PhD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:20 AM - 8:35 AM
Nov 09 2025
Washington, D.C.

Endpoints for phases 2 and 3 trials precirrhotic MetALD/ALD

Mazen Noureddin, MD, MHSc, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:35 AM - 8:50 AM
Nov 09 2025
Washington, D.C.

Endpoints in patients with compensated cirrhosis or compensated advanced chronic liver disease (cACLD)

Juan Pablo Arab, MD, FRCPC, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
8:50 AM - 9:05 AM
Nov 09 2025
Washington, D.C.

Endpoints in patients with decompensated cirrhosis

Debbie L Shawcross, BSc, MBBS, PhD, FRCP, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:05 AM - 9:25 AM
Nov 09 2025
Washington, D.C.

Panel Discussion 1 (All Presenters and FDA Speakers)

Grace Su, MD, FAASLD, Moderator
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:25 AM - 9:40 AM
Nov 09 2025
Washington, D.C.

Endpoints for Regulatory Approval in MASH-Related Fibrosis

Mary E. Rinella, MD, FAASLD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:40 AM - 9:55 AM
Nov 09 2025
Washington, D.C.

Endpoints for Regulatory Approval in Alcohol-associated Hepatitis

Gyongyi Szabo, MD, PhD, FAASLD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
9:55 AM - 10:10 AM
Nov 09 2025
Washington, D.C.

Endpoints for Regulatory Approval in Alpha-1 Anti-Trypsin Deficiency-Related Liver Disease

Rohit Loomba, MD, MHSc, FAASLD, Presenter
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
10:10 AM - 10:30 AM
Nov 09 2025
Washington, D.C.

Panel Discussion 2 (All Presenters and FDA Speakers)

Rotonya Carr, MD, FACP, Moderator
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD
10:27 AM - 10:27 AM
Nov 09 2025
Washington, D.C.

Panel Discussion

Caroline C. Duwaerts, Ph.D., Panelist
Charmaine Stewart, MD, FACP, AGAF, FAASLD, Panelist
Frank A Anania, MD, FAASLD, FACP, AGAF, Panelist
Ruby Mehta, MD, Panelist
Acute Liver Failure
Acute-on-Chronic Liver Failure
ALD
MASLD

Objectives

  • Understand current and emerging clinical and surrogate endpoints for MetALD, ALD, MASLD, and AATD.
  • To improve understanding of the regulatory pathways across a spectrum of chronic liver disease
  • Discuss the future of personalized and mechanism-based endpoints in liver disease trials.
Chair

Juan Pablo Arab, MD, FRCPC

Virginia Commonwealth University
Chair

Rohit Loomba, MD, MHSc, FAASLD

University of California, San Diego
Chair

Mazen Noureddin, MD, MHSc

Houston Methodist Hospital