Experts explore the dynamic interactions between the innate and adaptive immune systems in the context of liver fibrosis and inflammation, and provide insights into cutting-edge research and strategies for addressing liver fibrosis and associated inflammatory conditions. Key areas of focus include: (1) immune system roles—how innate immune cells (eg, macrophages, dendritic cells) and adaptive immune components (eg, T cells and B cells) communicate and influence hepatic tissue responses; (2) mechanisms of crosstalk—signaling pathways, cytokines, and cellular interactions that drive fibrosis and chronic liver inflammation; and (3) clinical implications—how immune crosstalk contributes to disease progression and identification of potential therapeutic targets to modulate the immune response and treat liver disorders.