MTE #11 Innate-Adaptive Immune Crosstalk in Hepatic Fibrosis and Inflammation

Description

Experts explore the dynamic interactions between the innate and adaptive immune systems in the context of liver fibrosis and inflammation, and provide insights into cutting-edge research and strategies for addressing liver fibrosis and associated inflammatory conditions. Key areas of focus include: (1) immune system roles—how innate immune cells (eg, macrophages, dendritic cells) and adaptive immune components (eg, T cells and B cells) communicate and influence hepatic tissue responses; (2) mechanisms of crosstalk—signaling pathways, cytokines, and cellular interactions that drive fibrosis and chronic liver inflammation; and (3) clinical implications—how immune crosstalk contributes to disease progression and identification of potential therapeutic targets to modulate the immune response and treat liver disorders.

     

Journey Maps

Objectives

  • Review how innate immune cells and adaptive immune components communicate and influence hepatic tissue responses.
  • Discuss the signaling pathways, cytokines, and cellular interactions that drive fibrosis and chronic liver inflammation.
  • Explain how immune crosstalk contributes to disease progression.
  • Name potential therapeutic targets to modulate the immune response and treat liver disorders.