MTE #18 Liver Regeneration Fibrosis: The Role of Liver Regeneration in Both Fibrosis Progression and Regression

Description

Explore the dual role of liver regeneration in the context of hepatic fibrosis. Experts provide a comprehensive discussion of the interplay between liver regeneration and fibrosis with a focus on therapeutic approaches to manage chronic liver disease. Topics include: (1) mechanisms of liver regeneration examining the molecular and cellular processes driving the liver's regenerative capacity; (2) fibrosis progression focused on how dysregulated regeneration can contribute to the accumulation of fibrotic tissue and chronic liver damage; (3) fibrosis regression exploring how effective liver regeneration can reverse fibrotic changes and restore normal liver function; and (4) the therapeutic implications of implementing strategies to modulate liver regeneration for promoting fibrosis resolution while minimizing the risk of further progression.

Journey Maps

Objectives

  • Explain the molecular and cellular processes that drive the liver's regenerative capacity.
  • Describe how dysregulated liver regeneration can contribute to the accumulation of fibrotic tissue and chronic liver damage.
  • Review how effective liver regeneration can reverse fibrotic changes and restore normal liver function.
  • Discuss the therapeutic implications of implementing strategies to modulate liver regeneration for promoting fibrosis resolution while minimizing the risk of further progression.