Explore the dual role of liver regeneration in the context of hepatic fibrosis. Experts provide a comprehensive discussion of the interplay between liver regeneration and fibrosis with a focus on therapeutic approaches to manage chronic liver disease. Topics include: (1) mechanisms of liver regeneration examining the molecular and cellular processes driving the liver's regenerative capacity; (2) fibrosis progression focused on how dysregulated regeneration can contribute to the accumulation of fibrotic tissue and chronic liver damage; (3) fibrosis regression exploring how effective liver regeneration can reverse fibrotic changes and restore normal liver function; and (4) the therapeutic implications of implementing strategies to modulate liver regeneration for promoting fibrosis resolution while minimizing the risk of further progression.
Explain the molecular and cellular processes that drive the liver's regenerative capacity.
Describe how dysregulated liver regeneration can contribute to the accumulation of fibrotic tissue and chronic liver damage.
Review how effective liver regeneration can reverse fibrotic changes and restore normal liver function.
Discuss the therapeutic implications of implementing strategies to modulate liver regeneration for promoting fibrosis resolution while minimizing the risk of further progression.