MTE #38 Cell Senescence in Liver Disease

Nov 10 2025
Convention Center: Room 144C, Level 1
12:45 PM - 1:30 PM
Ticketed Event

World Class Speakers

Stuart J. Forbes, MB CHB, FRCP(Ed), PhD
Discussion Leader

Stuart J. Forbes, MB CHB, FRCP(Ed), PhD

University of Edinburgh
Shuang (Sammi) Wang
Discussion Leader

Shuang (Sammi) Wang

Icahn School of Medicine at Mount Sinai

Description

Cell stress can lead to proliferative arrest (senescence), which can accelerate disease progression through a variety of mechanisms. Subject matter experts explore triggers and pathways that convert cells to a senescent, secretory phenotype. Session topics include: characteristics of cell senescence; the role of cellular senescence in the progression of chronic liver injury; types of cell populations affected (hepatocytes, cholangiocytes, hepatic stellate cells, and others); beneficial and harmful effects of cell senescence; molecular mechanisms; and potential therapeutic strategies. 

 

Journey Maps

Objectives

  • Explain the structural and functional changes that cells undergo during senescence.
  • Summarize the effects of senescence on various liver cell types, including hepatic stellate cells, cholangiocytes, hepatocytes, and endothelial cells.
  • Review the beneficial and harmful effects of cell senescence in liver disease.