Irina M Bochkis, PhD

Biography

I came to biology from engineering background and value the importance of a multidisciplinary approach to solve biomedical problems. I completed her Ph.D. training in Genomics & Computational Biology at University of Pennsylvania, where I studied transcriptional regulation in liver metabolism. For my postdoctoral fellowship, I trained at the Broad Institute, applying computational analysis of high-throughput data to epigenetic mechanisms in aging liver. I am both an experimental and computational biologist with extensive expertise in liver metabolism, transcriptional and chromatin regulation, and computational analysis of next-generation sequencing data.
My laboratory applies experimental and computational methods to identify genetic and epigenetic mechanisms regulating metabolism. We are focusing on understanding how genome-wide chromatin changes, which include chromatin accessibility, nuclear localization and dynamics, and genome organization, lead to physiological dysfunction. Our laboratory utilizes functional genomics, chromatin biology, physiology, and transcriptional regulation in a comprehensive approach to decipher molecular mechanisms in mammalian models of human metabolic disease.