Personalized Management of Portal Hypertension Across the Lifespan, Part 1

Portal hypertension is a complex, heterogeneous condition. Its presentation, mechanisms, and clinical consequences vary widely across age groups, etiologies, and individual patient characteristics. Traditional, uniform approaches to risk stratification and management are increasingly insufficient to address this complexity, particularly as new diagnostic tools, genetic insights, and therapeutic strategies emerge. This 2-part symposium—jointly planned by the Pediatric Liver Disorder and the Portal Hypertension Special Interest Groups—explores personalized approaches to portal hypertension across the lifespan, from childhood to adulthood, integrating pediatric and adult perspectives. Through case-based discussions and expert-led presentations, the sessions address contemporary strategies for risk stratification, management of portal vein thrombosis, and acute and long-term complications of portal hypertension. Presenters particularly emphasize tailoring decisions based on disease mechanisms, patient-specific factors, and evolving evidence, with the goal of improving outcomes and optimizing care pathways in both pediatric and adult populations.