ALEXANDRIA, Virginia — The American Association for the Study of Liver Diseases (AASLD) and the American Society of Transplantation (AST) are pleased to announce the latest Practice Guideline on Adult Liver Transplantation: Diagnosis and Management of Graft-Related Complications published in Liver Transplantation, the premier journal equipping clinicians and researchers with the latest insights in this evolving specialty.
Driven by significant advances in immunosuppression and surgical techniques, patient outcomes in liver transplantation have improved markedly over the last decade. However, challenges remain in donor utilization and long-term graft health. This new guideline provides a comprehensive framework for managing key post-transplant issues, including graft rejection, recurrent disease, and immunosuppressive strategies and discusses the use of machine perfusion.
Developed by a multidisciplinary panel of transplant hepatologists, surgeons, pathologists, and psychiatrists, the guideline is rooted in the latest scientific evidence and expert consensus.
“This guideline addresses many of the real-world challenges clinicians face in managing patients after liver transplantation,” said Helen S. Te, MD, FAASLD, University of Chicago Medicine. “It offers practical, evidence-based recommendations for improving allograft outcomes and long-term patient care.”
The guideline also identifies areas in need of further research, including the prevention and treatment of recurrent alcohol-associated and metabolic dysfunction-associated steatotic liver disease, as well as immune-mediated liver diseases.
“As the field of liver transplantation evolves, it’s essential that our clinical guidance keeps pace,” said Dr. Thomas D. Schiano, MD, FAASLD, The Mount Sinai Medical Center. “This guideline not only synthesizes the best available evidence but also highlights important gaps where further research is needed to optimize graft survival and patient outcomes.”
The new guideline underscores AASLD’s continued commitment to advancing the science and practice of hepatology, and supporting clinicians in delivering high-quality, individualized care to liver transplant recipients.
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About AASLD
The American Association for the Study of Liver Diseases (AASLD) is the leading organization of scientists and health care professionals committed to preventing and curing liver disease. AASLD fosters research that leads to improved treatment options for millions of liver disease patients and advances the science and practice of hepatology through educational conferences, training programs, professional publications, and partnerships with government agencies and sister societies.
About AST
The American Society of Transplantation (AST) is the largest transplant organization in North America and is recognized as the premier society for transplant professionals. Founded in 1982, the AST currently has over 5,000 members dedicated to advancing the field of transplantation and improving patient care by promoting research, education, advocacy, and organ donation.
About Liver Transplantation
Liver Transplantation, a publication of the AASLD and the International Liver Transplantation Society (ILTS ), delivers current, peer-reviewed articles on liver transplantation, liver surgery, and chronic liver disease—the information necessary to keep abreast of this evolving specialty. Follow the journal on X at @LTxJournal.