Swati Joshi‐Barve, Shirish S. Barve, Waseem Butt, Jon Klein, Craig J. McClain – 30 December 2003 – Breakdown of cellular proteins is a highly regulated process, and the ubiquitin‐proteasome pathway is the major proteolytic system in the cell. It regulates the levels of numerous proteins that control gene expression and cell division, as well as responses to stress and inflammation. Recent studies have reported abnormalities in proteasome function in alcoholic liver disease (ALD).

Frederik Nevens, Tania Roskams, Hans Van Vlierberghe, Yves Horsmans, Dirk Sprengers, Ann Elewaut, Valeer Desmet, Geert Leroux‐Roels, Emmanuel Quinaux, Erik Depla, Stephanie Dincq, Christine Vander Stichele, Geert Maertens, Frank Hulstaert – 30 December 2003 – New treatments are needed for chronic hepatitis C patients in whom viral clearance cannot be achieved. Thirty‐five chronic hepatitis C patients (genotype 1) were randomized to receive 20 μg of recombinant HCV E1 (E1) (n = 26) or placebo (n = 9) intramuscularly at weeks 0, 4, 8, 12, and 24.

Gordon Jung‐Hyuk Park, Peter Harry Katelaris, D. Brian Jones, Francis Seow, David George Le Couteur, Meng Chong Ngu – 30 December 2003 – The properties of caffeine render it an ideal substrate for a quantitative test of liver function. The aim of this study was to determine whether the caffeine breath test (CBT) using orally administered 13C‐caffeine correlates reliably with plasma caffeine clearance and reflects varying degrees of liver dysfunction. The CBT was performed in 25 healthy controls; 20 subjects with noncirrhotic, chronic hepatitis B or C; and 20 subjects with cirrhosis.

Olaf R. F. Mook, Wilma M. Frederiks, Cornelis J. F. Van Noorden – 30 December 2003

Carlos Margarit, Itxarone Bilbao, Ramón Charco, José Luis Lázaro, Ernest Hidalgo, Elena Allende, Enrique Murio – 30 December 2003 – Auxiliary liver transplantation for patients with fulminant hepatic failure supports the patient's failing liver for a period of time until the native liver (NL) has recovered and immunosuppression can be withdrawn.

John G. O'Grady – 30 December 2003 – Key Points

Vincent T. Armenti, Steven K. Herrine, John S. Radomski, Michael J. Moritz – 30 December 2003 – The first known posttransplantation pregnancy was in 1958 in a renal transplant recipient who had received a kidney from her identical twin sister. The first known posttransplantation pregnancy in a liver transplant recipient was in 1978. Information available from female kidney transplant recipients helped in the decision making involved in the management of this case, as well as those that followed.

Amadeo Marcos – 30 December 2003 – Key Points

Robyn S. Shapiro, Mark Adams – 30 December 2003 – Key Points

Stephen P. Pereira, Louise M. Howard, Paolo Muiesan, Mohammed Rela, Nigel Heaton, Roger Williams – 30 December 2003 – There are few data on predictive factors for alcohol relapse or long‐term functional outcome after liver transplantation for alcoholic liver disease (ALD).