Is genotype 3 of the hepatitis C virus the new villain?

Nicolas Goossens, Francesco Negro – 24 October 2013 – Genotype 3 of the hepatitis C virus (HCV) has been long considered an easy‐to‐treat infection, with higher cure rates (∼70%) than other viral genotypes with the standard combination of pegylated interferon‐α and ribavirin. However, the relative insensitivity of this genotype to most protease inhibitors and the recent unexpected data on decreased effectiveness of sofosbuvir have raised questions on how to achieve universal cure, a goal that seems reasonable for other genotypes.

Idiopathic portal hypertension: Natural history and long‐term outcome

Sith Siramolpiwat, Susana Seijo, Rosa Miquel, Annalisa Berzigotti, Angeles Garcia‐Criado, Anna Darnell, Fanny Turon, Virginia Hernandez‐Gea, Jaume Bosch, Juan Carlos Garcia‐Pagán – 23 October 2013 – Idiopathic portal hypertension (IPH) is a rare cause of intrahepatic portal hypertension. Data on natural history and prognosis of IPH are limited. We sought to describe the complications and long‐tem outcome of IPH by retrospectively studying 69 biopsy‐proven cases of IPH. Mean duration of follow‐up was 6.7 ± 4.6 years.

Idiopathic portal hypertension: Natural history and long‐term outcome

Sith Siramolpiwat, Susana Seijo, Rosa Miquel, Annalisa Berzigotti, Angeles Garcia‐Criado, Anna Darnell, Fanny Turon, Virginia Hernandez‐Gea, Jaume Bosch, Juan Carlos Garcia‐Pagán – 23 October 2013 – Idiopathic portal hypertension (IPH) is a rare cause of intrahepatic portal hypertension. Data on natural history and prognosis of IPH are limited. We sought to describe the complications and long‐tem outcome of IPH by retrospectively studying 69 biopsy‐proven cases of IPH. Mean duration of follow‐up was 6.7 ± 4.6 years.

Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

Bryan C. Fuchs, Yujin Hoshida, Tsutomu Fujii, Lan Wei, Suguru Yamada, Gregory Y. Lauwers, Christopher M. McGinn, Danielle K. DePeralta, Xintong Chen, Toshihiko Kuroda, Michael Lanuti, Anthony D. Schmitt, Supriya Gupta, Andrew Crenshaw, Robert Onofrio, Bradley Taylor, Wendy Winckler, Nabeel Bardeesy, Peter Caravan, Todd R. Golub, Kenneth K. Tanabe – 21 October 2013 – Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related mortality in the United States.

The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis

Darragh Duffy, Rasha Mamdouh, Melissa Laird, Charlotte Soneson, Lenaig Le Fouler, Maï El‐Daly, Armanda Casrouge, Jérémie Decalf, Amal Abbas, Noha Sharaf Eldin, Magnus Fontes, Mohamed Abdel‐Hamid, Mostafa K. Mohamed, Mona Rafik, Arnaud Fontanet, Matthew L. Albert – 21 October 2013 – Viral hepatitis is the leading cause of liver disease worldwide and can be caused by several agents, including hepatitis A (HAV), B (HBV), and C (HCV) virus.

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