Telomere length is associated with intima‐media thickness in pediatric liver transplant patients: A prospective cohort study

Nima Memaran, Hannes Wilke, Rizky I. Sugianto, Ulrich Baumann, Elena Bauer, Maxine Swallow, Esther Beuke, Norman Junge, Eva D. Pfister, Carl Grabitz, Nicolas Richter, Imeke Goldschmidt, Bernhard M. W. Schmidt, Anette Melk – 5 June 2022 – Leukocyte telomere length (LTL) is a marker for biological age. Pediatric liver transplant recipients show a high rate of subclinical atherosclerosis, indicated by elevated intima‐media thickness (IMT). We hypothesized that atherosclerosis is associated with biological age in these patients and investigated the course of LTL over time.

Associations between six dietary habits and risk of hepatocellular carcinoma: A Mendelian randomization study

Yunyang Deng, Junjie Huang, Martin C. S. Wong – 5 June 2022 – Diet is reported to be associated with hepatocellular carcinoma (HCC), but whether there is a causal relationship remains unclear. This study aimed to explore the potential causal associations between dietary habits and HCC risk using Mendelian randomization in an East Asian population.

Elevated liver enzymes predict morbidity and mortality despite antiviral cure in patients with chronic hepatitis C: Data from the German Hepatitis C‐Registry

Frank Tacke, Hartwig Klinker, Klaus H. W. Boeker, Uta Merle, Ralph Link, Peter Buggisch, Dietrich Hüppe, Markus Cornberg, Christoph Sarrazin, Heiner Wedemeyer, Thomas Berg, Stefan Mauss, DHC‐R – 4 June 2022 – While direct‐acting antivirals (DAAs) cure chronic hepatitis C virus (HCV) infection in almost all patients, some patients remain at risk of liver disease despite HCV cure.

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper – 4 June 2022 – Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding, renal injury, falls, and hepatic encephalopathy.

The role of transjugular intrahepatic portosystemic shunt in patients with cirrhosis and ascites: Recent evolution and open questions

Pierre Deltenre, Alberto Zanetto, Dario Saltini, Christophe Moreno, Filippo Schepis – 3 June 2022 – In selected patients with cirrhosis and ascites, transjugular intrahepatic portosystemic shunt (TIPS) placement improves control of ascites and may reduce mortality. In this review, we summarize the current knowledge concerning the use of TIPS for the treatment of ascites in patients with cirrhosis, from pathophysiology of ascites formation to hemodynamic consequences, patient selection, and technical issues of TIPS insertion.

Burden of early hospitalization after simultaneous liver–kidney transplantation: Results from the US Multicenter SLKT Consortium

Pratima Sharma, Jiaheng Xie, Leyi Wang, Min Zhang, John Magee, Adeline Answine, Pranab Barman, Jennifer Jo, Jasmine Sinha, Aaron Schluger, Gabriel J. Perreault, Kara E. Walters, Giuseppe Cullaro, Randi Wong, Natalia Filipek, Scott W. Biggins, Jennifer C. Lai, Lisa B. VanWagner, Elizabeth C. Verna, Yuval A. Patel – 3 June 2022 – The burden of early hospitalization (within 6 months) following simultaneous liver–kidney transplant (SLKT) is not known.

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