R. Mark Ghobrial – 26 January 2007

Michael R. Lucey – 26 January 2007

Mubeen A. Jafri, Amit D. Tevar, Mark Lucia, Thav Thambi‐Pillai, Andreas Karachristos, Leslie Trumbull, Joseph F. Buell, Mark J. Thomas, Michael J. Hanaway, E. Steve Woodle, Steven M. Rudich – 26 January 2007 – Primary fascial closure is often difficult after adult orthotopic liver transplantation (OLT), complicated by donor‐to‐recipient graft size mismatch, post‐reperfusion hepatic edema, coagulopathy, or intestinal edema. Attempts at closing the abdomen under these circumstances can cause increase in intra‐abdominal pressures, resulting in significant complications, including graft loss.

Claus U. Niemann, John Feiner, Matthias Behrends, Helge Eilers, Nancy L. Ascher, John P. Roberts – 26 January 2007 – Low central venous pressure (CVP) has been advocated during liver resection to reduce blood loss and transfusion requirements. As a consequence, CVP catheter placement has been considered essential for hepatic surgery, including living donor hepatectomies. We retrospectively analyzed whether intraoperative management without CVP monitoring influenced fluid administration, blood loss, and patient outcome.

T. Peter Kingham, Umer I. Chaudhry, George Plitas, Steven C. Katz, Jesse Raab, Ronald P. DeMatteo – 26 January 2007 – The liver has unique immunological properties. Although dendritic cells (DCs) are central mediators of immune regulation, little is known about liver DCs. Plasmacytoid DCs (pDCs) are a recently identified subtype of murine liver DC. We sought to define the function of freshly isolated murine liver pDCs.

Eugene Schiff, Ching‐Lung Lai, Stephanos Hadziyannis, Peter Neuhaus, Norah Terrault, Massimo Colombo, Hans Tillmann, Didier Samuel, Stefan Zeuzem, Jean‐Pierre Villeneuve, Sarah Arterburn, Katyna Borroto‐Esoda, Carol Brosgart, Steven Chuck – 11 January 2007 – Wait‐listed (n = 226) or post–liver transplantation (n = 241) chronic hepatitis B (CHB) patients with lamivudine‐resistant hepatitis B virus (HBV) were treated with adefovir dipivoxil for a median of 39 and 99 weeks, respectively.

Yuichiro Otsuka, John P. Duffy, Sammy Saab, Douglas G. Farmer, Rafik M. Ghobrial, Jonathan R. Hiatt, Ronald W. Busuttil – 11 January 2007 – Postoperative liver failure (PLF) is a rare but often fatal complication of major hepatic resection. Use of orthotopic liver transplantation (OLT) for PLF remains undefined. We conducted a retrospective review of 435 patients who underwent hepatic resection between 1990 and 2004; 9 of them (2.0%) developed PLF.

Kathleen M. Loomes, Pierre Russo, Matthew Ryan, Anthony Nelson, Lara Underkoffler, Curtis Glover, Hong Fu, Thomas Gridley, Klaus H. Kaestner, Rebecca J. Oakey – 5 January 2007 – The Notch signaling pathway is involved in determination of cell fate and control of cell proliferation in multiple organ systems. Jag1 encodes a ligand in the Notch pathway and has been identified as the disease‐causing gene for the developmental disorder Alagille syndrome. Evidence from the study of human disease and mouse models has implicated Jag1 as having an important role in the development of bile ducts.

Ram M. Subramanian, Navdeep Chandel, G. R. Scott Budinger, Paul T. Schumacker – 5 January 2007 – Following prolonged hypoxia, mammalian cells invoke adaptive mechanisms to enhance oxygen delivery and promote energy conservation.

Calivarathan Latchoumycandane, Catherine W. Goh, Michie M.K. Ong, Urs A. Boelsterli – 5 January 2007 – Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses but which can precipitate liver injury at high doses. We have previously found that the antirheumatic drug leflunomide is a potent inhibitor of APAP toxicity in cultured human hepatocytes, protecting them from mitochondria‐mediated cell death by inhibiting the mitochondrial permeability transition.