James D. Perkins – 23 May 2006
Jean F. Botha, Wendy J. Grant, Clarivet Torres, Angie K. Iverson, Debra L. Sudan, Byers W. Shaw, Alan N. Langnas – 18 May 2006 – Infants with short bowel syndrome (SBS) and associated liver failure are often referred for combined liver/intestinal transplantation. We speculated that in some young children, nutritional autonomy would be possible with restoration of normal liver function. Features we believed to predict nutritional autonomy include history of at least 50% enteral tolerance, age less than 2 yr, and no underlying intestinal disease.
Giorgio Ercolani, Gian Luca Grazi, Matteo Ravaioli, Massimo Del Gaudio, Matteo Cescon, Giovanni Varotti, Giovanni Ramacciato, Gaetano Vetrone, Matteo Zanello, Antonio Daniele Pinna – 18 May 2006 – Impact of hepatitis C virus (HCV) recurrence on long‐term outcome after orthotopic liver transplantation (OLT) is highly variable, and the role of retransplantation is still debated. From 1996 to 2003, 131 OLT with histologically proven HCV recurrence and 6 months of follow‐up were retrospectively reviewed. One and 5‐yr overall survivals were 90.7 and 81.3%, respectively.
Ichiro Tsunematsu, Yasuhiro Ogura, Kayoko Inoue, Akio Koizumi, Nobuhiko Tanigawa, Koichi Tanaka – 18 May 2006 – Adult‐to‐adult living donor liver transplantation (ALDLT) has been accepted as an important option for end‐stage liver disease, but information regarding the risk factors remains fragmentary. We aimed to establish a predictive model for 90‐day survival. In the first step, a total of 286 cases who had received primary ALDLT using a right lobe graft between 1998 and 2004 were randomly divided into 2 cohorts at a ratio of 2:1 (191 vs. 95 recipients).
Luca Aldrighetti, Carlo Pulitanò, Marcella Arru, Renato Finazzi, Marco Catena, Laura Soldini, Laura Comotti, Gianfranco Ferla – 18 May 2006 – Hepatic injury secondary to warm ischemia‐reperfusion (I/R) injury and alterations in haemostatic parameters are often unavoidable events after major hepatic resection. The release of inflammatory mediator is believed to play a significant role in the genesis of these events. It has been suggested that preoperative steroid administration may reduce I/R injury and improve several aspects of the surgical stress response.
Thierry Gustot, Arnaud Lemmers, Christophe Moreno, Nathalie Nagy, Eric Quertinmont, Charles Nicaise, Denis Franchimont, Hubert Louis, Jacques Devière, Olivier Le Moine – 20 April 2006 – Gut‐derived, endotoxin‐mediated hepatocellular damage has been postulated to play a crucial role in the pathogenesis of alcohol‐induced liver injury in rodents. Endotoxins induce production of tumor necrosis factor α (TNF‐α) by Kupffer cells via Toll‐like receptor (TLR) 4 and contribute to liver injury. This study addressed the contribution of other TLRs and ligands to alcoholic fatty liver.
Albert Mennone, Carol J. Soroka, Shi‐Ying Cai, Kathy Harry, Masashi Adachi, Lee Hagey, John D. Schuetz, James L. Boyer – 20 April 2006 – Mrp4 is a member of the multidrug resistance–associated gene family that is expressed on the basolateral membrane of hepatocytes and undergoes adaptive upregulation in response to cholestatic injury or bile acid feeding. However, the relative importance of Mrp4 in a protective adaptive response to cholestatic injury is not known.
George N. Ioannou, Noel S. Weiss, Edward J. Boyko, Dariush Mozaffarian, Sum P. Lee – 20 April 2006 – In the United States, elevated serum alanine aminotransferase (ALT) activity in the absence of viral hepatitis or excessive alcohol consumption is most commonly attributed to nonalcoholic fatty liver disease (NAFLD). NAFLD is related to predictors of coronary heart disease (CHD) such as insulin resistance and central obesity. We examined the association between elevated serum ALT activity and the 10‐year risk of CHD as estimated using the Framingham risk score (FRS).
Kevin D. Mullen, Ravi K. Ghanta, Brian S. Putka – 20 April 2006
20 April 2006