Maid (GCIP) is involved in cell cycle control of hepatocytes

Eva Sonnenberg‐Riethmacher, Torsten Wüstefeld, Michaela Miehe, Christian Trautwein, Dieter Riethmacher – 26 January 2007 – The function of Maid (GCIP), a cyclinD‐binding helix‐loop‐helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid‐deficient mice—in contrast to wild‐type controls—develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH).

A national French survey on the use of growth factors as adjuvant treatment of chronic hepatitis C

Thierry Thévenot, Jean‐François Cadranel, Vincent Di Martino, Alexandre Pariente, Xavier Causse, Christophe Renou, Hervé Hagege, Jacques Denis, Françoise Lunel‐Fabiani – 26 January 2007 – We conducted a national retrospective survey on hospital practitioners to evaluate the magnitude of erythropoietin (EPO) or granulocyte colony‐stimulating factor (G‐CSF) prescriptions in patients treated for chronic hepatitis C. Four hundred seventy‐one questionnaires were sent, and 274 practitioners (58.2%) responded. Forty‐six percent of practitioners used EPO, and 31% used G‐CSF.

Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma

Teresa Pollicino, Giuseppina Raffa, Lucy Costantino, Antonella Lisa, Cesare Campello, Giovanni Squadrito, Massimo Levrero, Giovanni Raimondo – 26 January 2007 – Occult HBV infection is characterized by the persistence of HBV DNA in the liver of individuals negative for HBV surface antigen (HBsAg). Occult HBV may exist in the hepatocytes as a free genome, although the factors responsible for the very low viral replication and gene expression usually observed in this peculiar kind of infection are mostly unknown.

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