Preservation of steatotic livers in IGL‐1 solution

Ismail Ben Mosbah, Joan Roselló‐Catafau, Rosa Franco‐Gou, Hassen Ben Abdennebi, Dalila Saidane, Silvina Ramella‐Virieux, Olivier Boillot, Carmen Peralta – 24 May 2006 – A new Institut Georges Lopez (IGL‐1) solution was used to preserve steatotic livers. Steatotic (obese [Ob]) and nonsteatotic (lean [Ln]) livers from Zücker rats (n = 16, 8 Ln and 8 Ob) were preserved for 24 hours at 4°C in University of Wisconsin (UW) or IGL‐1 solution, respectively, and then perfused ex vivo for 2 hours at 37°C.

Bacterial‐ and fungal‐positive cultures in organ donors: Clinical impact in liver transplantation

Elisabetta Cerutti, Chiara Stratta, Renato Romagnoli, Roberto Serra, Mirella Lepore, Fabrizio Fop, Luciana Mascia, Francesco Lupo, Alessandro Franchello, Angelo Panio, Mauro Salizzoni – 24 May 2006 – Infection transmission from donor to recipient is a dreadful complication in transplantation. Although bacteremia was previously detected in 5% of donors without negative impact on recipient outcome, the current expansion of graft pool requires consideration of the infectious risk associated with suboptimal donors.

The importance of CD25+CD4+ regulatory T cells in mouse hepatic allograft tolerance

Xiaofeng Jiang, Miwa Morita, Atsushi Sugioka, Michishige Harada, Satoshi Kojo, Hiroshi Wakao, Hiroshi Watarai, Nobuhiro Ohkohchi, Masaru Taniguchi, Ken‐ichiro Seino – 24 May 2006 – In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25+CD4+ regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these cells to tolerance in mouse liver transplantation has not been elucidated.

Portal vein reconstruction in adult living donor liver transplantation using cryopreserved vein grafts

Yasuhiko Sugawara, Masatoshi Makuuchi, Sumihito Tamura, Yuichi Matsui, Junichi Kaneko, Kiyoshi Hasegawa, Hiroshi Imamura, Norihiro Kokudo, Noboru Motomura, Shinichi Takamoto – 24 May 2006 – No data are available for the management of venous jump or interposition conduits for portal vein (PV) reconstruction in adult living donor liver transplantation (LDLT). The feasibility of using cryopreserved vein grafts as PV conduits was examined. Cryopreserved vein (n = 23) was used as a patch, interposition, or jump graft.

Lessons learned from 1,000 living donor liver transplantations in a single center: How to make living donations safe

Shin Hwang, Sung‐Gyu Lee, Young‐Joo Lee, Kyu‐Bo Sung, Kwang‐Min Park, Ki‐Hun Kim, Chul‐Soo Ahn, Deok‐Bog Moon, Gyu‐Sam Hwang, Kyung‐Mo Kim, Tae‐Yong Ha, Dong‐Sik Kim, Jae‐Pil Jung, Gi‐Won Song – 23 May 2006 – Serious complications have occurred in a considerable proportion of living donors of liver transplants, but data from a single high‐volume center has rarely been available. We analyzed the medical records of donors and recipients of the first 1,000 living donor liver transplants, performed at Asan Medical Center from December 1994 to June 2005, with a focus on donor safety.

Living donor liver transplantation as a second‐line therapeutic strategy for patients with hepatocellular carcinoma

Yasutsugu Takada, Mikiko Ueda, Takashi Ito, Seisuke Sakamoto, Hironori Haga, Yoji Maetani, Kohei Ogawa, Mureo Kasahara, Fumitaka Oike, Hiroto Egawa, Koichi Tanaka – 23 May 2006 – Living donor liver transplantation (LDLT) has evolved to represent an important surgical strategy for patients with hepatocellular carcinoma (HCC). However, due to disadvantages, including donor risks and higher rates of perioperative complications, LDLT has been considered as a second‐line treatment in Japan.

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