Characterization of premature liver polyploidy in DNA repair (Ercc1)‐deficient mice

Michael D. Chipchase, Mary O'Neill, David W. Melton – 7 March 2007 – ERCC1‐XPF is the endonuclease that cuts 5′ of the damage in nucleotide excision repair (NER). Unlike other NER proteins, ERCC1‐XPF is also involved in recombination and the repair of DNA interstrand cross‐links. Unique among the NER gene knockouts, Ercc1 null mice are severely runted with high levels of hepatocyte polyploidy. To understand the link between DNA repair deficiency and polyploidy we have compared the premature polyploidy in Ercc1 null liver with the normal development of polyploidy in aging control mice.

Myeloperoxidase‐positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide‐mediated reactions

Chih‐Te Wu, Jason P. Eiserich, Aftab A. Ansari, Ross L. Coppel, Sripriya Balasubramanian, Christopher L. Bowlus, M. Eric Gershwin, Judy Van De Water – 7 March 2007 – Previous studies have suggested that increased nitric oxide (NO)‐mediated products are found in the livers of subjects with primary biliary cirrhosis (PBC), but the mechanisms involved remain enigmatic.

Polycystic disease of the liver

Gregory T. Everson, Matthew R. G. Taylor, R. Brian Doctor – 7 March 2007 – Autosomal dominant polycystic disease is genetically heterogeneous with mutations in two distinct genes predisposing to the combination of renal and liver cysts (AD‐PKD1 and AD‐PKD2) and mutations in a third gene yielding isolated liver cysts (the polycystic liver disease gene). Transcription and translation of the PKD1 gene produces polycystin‐1, an integral membrane protein that may serve as an extracellular receptor.

Factors associated with fulminant liver failure during an outbreak among injection drug users with acute hepatitis B

Richard S. Garfein, William A. Bower, Cherry M. Loney, Yvan J. F. Hutin, Guo‐Liang Xia, Jaspaul Jawanda, Amy V. Groom, Omana V. Nainan, James S. Murphy, Beth P. Bell – 7 March 2007 – Death related to acute hepatitis B occurs in approximately 1% of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection drug users (IDUs) resulting in several deaths. We conducted a case‐control study of fulminant (case patients) and nonfulminant (control patients) HBV infections. We directly sequenced the entire HBV genome from fulminant and nonfulminant cases.

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