Angelos Afroudakis, Neil Kaplowitz – 1 January 1981 – The liver histopathology in 40 liver biopsies from 24 patients with verified chronic common bile duct stenosis due to chronic alcoholic pancreatitis has been reviewed code‐blinded. This represents an 8% prevalence of this complication in approximately 300 patients with alcoholic pancreatitis screened biochemically for alkaline phosphatase >two‐fold for >1 month. The majority were anicteric with no symptoms other than from acute exacerbations of chronic pancreatitis.

Michael A. Dunn, Sam Seifter, Penelope K. Hait – 1 January 1981 – Proline, a critical substrate for collagen synthesis, is increased in liver undergoing fibrosis. In mice with schistosomiasis, the incorporation of proline into collagen occurs within liver granulomas. To study the interaction of liver cells and granulomas in the development of fibrosis, we assayed the enzymes that catalyze the formation and degradation of proline in isolated granulomas and liver.

David A. Shafritz, Michael C. Kew – 1 January 1981 – DNA extracts from hepatocellular carcinomas of 13 patients from South Africa were examined for hepatitis B virus (HBV) DNA sequences by molecular hybridization using [32P]‐labeled recombinant, cloned, and purified HBV‐DNA. Eight patients were HBV carriers as demonstrated by the presence of hepatitis B surface antigen (HBsAg) in their serum, and each of these patients had HBV‐DNA sequences in hepatocellular carcinoma tissue. Five patients who were not HBsAg carriers, did not have HBV‐DNA in their tumors.

Anasticio M. Hoyumpa, Rashmi Patwardhan, Michael Maples, Paul V. Desmond, Raymond F. Johnson, Alicia P. Sinclair, Steven Schenker – 1 January 1981 – The disposition of chlordiazepoxide (Librium®) and diazepam (Valium®), compounds which are initially degraded by oxidative processes, differs from that of oxazepam (Serax®) and lorazepam (Ativan®), drugs which are inactivated by conjugation with glucuronic acid. Liver disease and cimetidine impair the elimination of the former agents, but not the latter two benzodiazepines.

Alfred M. Prince – 1 January 1981