Pathology of cytoskeleton of liver cells: Demonstration of mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes

Helmut Denk, Werner W. Franke, Brigitte Dragosics, Ingrid Zeiler – 1 January 1981 – A cytoskeleton fraction enriched in intermediate‐sized filaments and resistant to high and low salt buffer containing Triton X‐100 was prepared from dissociated mouse liver cells and mouse liver homogenates. One‐dimensional sodium dodecyl sulfate‐polyacrylamide gel electrophoresis revealed a family of polypeptides in the relative molecular weight (Mr) range from 41,000 to 55,000, with two polypeptides (component A, Mr 55,000; component D, Mr 48,000) as major constituents.

Attenuation of the ethanol‐induced hepatic redox change after chronic alcohol consumption in baboons: Metabolic consequences in vivo and in vitro

Mikko P. Salaspuro, Spencer Shaw, Elizabeth Jayatilleke, William A. Ross, Charles S. Lieber – 1 January 1981 – Acute ethanol administration results in increased hepatic NADH/NAD+ ratio and inhibition of galactose elimination, tricarboxylic acid cycle activity, and fatty acid oxidation. To determine how this redox change is affected by chronic alcohol consumption and to assess the resulting metabolic consequences, we studied baboons which were fed alcohol as 50% of their total calories.

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