James P. Nolan – 1 September 1981

Shyamal K. Maitra, Daniel Rachmilewitz, David Eberle, Neil Kaplowitz – 1 September 1981 – Endotoxin is known to cause a dose‐dependent impairment of hepatic bile secretion, organic anion excretion, and activity of Na+, K+‐activated ATPase. Since it is possible that this impaired excretory function is a result of direct interaction of endotoxin with hepatocytes, we examined: (a) the excretion of endotoxin into bile, and (b) its association with an hepatocyte‐enriched, Kupffer cell‐depleted population of liver cells.

Mary Jeanne Kreek, Marcus A. Rothschild, Murray Oratz, Joseph Mongelli, Anne C. Handley – 1 September 1981 – This study was performed as an initial step in systematically defining the hepatic interactions between ethanol and opioids using a controlled in vitro system. The acute effects of ethanol on the initial uptake and distribution of long‐ and short‐acting narcotics were studied using isolated rabbit liver perfused with rabbit blood without or with ethanol.

W. Howard Evans – 1 September 1981 – Traffic in the environs of regions of the hepatocyte's plasma membrane is heavy. A fuller understanding of the nature and control of this membrane traffic depends on the appreciation of the hepatocyte's plasma membrane. This conglomerate consists of a receptor‐rich and metabolically dynamic blood‐sinusoidal domain which is separated from the bile canalicular domain by a lateral domain which participates in cell‐cell interactions (1, 2).

Harvey J. Alter, Thomas C. Chalmers – 1 September 1981

Rosemary van Hoorn‐Hickman, Del Kahn, Jewel Green, Heather A. Macleod, John Terblanche – 1 July 1981 – An attempt was made to transfer a stimulator substance from the perfusate of partially hepatectomized perfused livers to the portal stump of portacaval‐shunted pig recipients. Blood was either cross‐circulated with recipients during perfusion or was given by exchange tranfusion after 4 hr perfusion. There was an increase in thymidine kinase activity and mitotic indices in biopsies from portacaval‐shunted recipients whether perfusions were performed 2 or 4 days after partial hepatectomy.

H. Franklin Herlong, Robert M. Russell, Willis C. Maddrey – 1 July 1981 – Eleven patients with primary biliary cirrhosis were surveyed for evidence of vitamin A and zinc deficiencies. Vitamin A deficiency manifested as a low serum vitamin A concentration and abnormal dark adaptation was present in 9 of the 11 patients. A low serum zinc level was present in four patients who were also vitamin A deficient. All seven patients who received p.o. vitamin A therapy with 25,000 to 50,000 units per day for 4 to 12 weeks achieved normal vitamin A levels.

Naohito Ohmi, Irwin M. Arias – 1 July 1981 – Ligandin was quantitated by radioimmunoassay in serum and, when possible, in tumors from patients with primary hepatocellular carcinoma, massive hepatic metastasis or nonhepatic primary neoplasms, and in rats and athymic (nu/nu) mice bearing transplantable ligandin‐containing or nonligandin‐containing rat hepatocellular carcinomas.

1 July 1981

Hideki Ohkubo, Kunio Okuda, Shinji Iida – 1 July 1981 – The kinetics of plasma clearance of indocyanine green and bromosulfophthalein were studied in 49 consecutive patients with chronic unconjugated hyperbilirubinemia. Forty‐four patients had Gilbert's syndrome whereas five patients had impaired hepatic uptake of indocyanine green and virtually normal hepatic bromosulfophthalein uptake. There was no difference in bilirubin metabolism between the two groups.