Hepatic lysosomal copper protein in dogs with an inherited copper toxicosis

Gerald F. Johnson, Anatol G. Morell, Richard J. Stockert, Irmin Sternlieb – 1 May 1981 – Hepatic copper overload inherited as an autosomal recessive trait in Bedlington Terriers is characterized by the presence of hepatocellular lysosomal granules of unusually high specific gravity and electron density which contain at least two thirds of the total hepatic copper.

A low molecular weight binding protein for organic anions (Z protein) from human hepatic cytosol: Purification and quantitation

Kazuaki Kamisaka, Hidenori Maezawa, Tooru Inagaki, Kenichi Okano – 1 May 1981 – Human Z protein from liver was purified to homogeneity. The protein has a molecular weight of 11,000 and an isoelectric point of pH 5.8. Circular dichroism spectra of Z protein‐bilirubin (uncon‐jugated and diglucuronide) complexes revealed two ellipticity extrema, a negative peak at 460 nm, and a positive peak at 410 nm. Human serum albumin had a higher affinity for bilirubin than did Z protein.

Increase in ascites white blood cell and protein concentrations during diuresis in patients with chronic liver disease

John C. Hoefs – 1 May 1981 – Serum and ascites protein concentration and ascites cell concentration alterations were determined serially during diuresis in 27 patients with uncomplicated liver disease. The total protein concentration in ascites increased from 1.38 ± 0.96 gm% to 2.86 ± 1.28 gm% (p < 0.001); the serum protein concentration from 6.26 ± 0.81 gm% to 7.24 ± 0.93 gm% (p < 0.001), and the ascites to serum ratio of the total protein concentration from 0.21 ± 0.13 to 0.38 ± 0.14 (p < 0.001).

δ antigen in hepatitis B: Immunohistology of frozen and paraffin‐embedded liver biopsies and relation to HBV infection

Elisabeth St. Öcklin, Fred Gudat, Gunthild Krey, Ursula Dürmüller, Markus Gasser, Martin Schmid, Georg Stalder, Leonardo Bianchi – 1 May 1981 – The finding that the recently described hepatitis B (HB)‐associated delta antigen (δ Ag) is preserved in pronase‐treated, formalin‐fixed paraffin sections allowed a combined prospective and retrospective immunohistological study of its occurrence in 571 liver biopsies.

Modification of galactosamine‐induced liver injury in rats by reticuloendothelial system stimulation or depression

Ali Al‐Tuwaijri, Kemal Akdamar, Nicholas R. di Luzio – 1 March 1981 – The reticuloendothelial system has been implicated in galactosamine‐induced liver injury because of a correlation between phagocytic alterations induced by colloidal carbon or endotoxin, and development of liver necrosis. To evaluate this concept, the influence of galactosamine on liver function and histology was determined in rats in which the reticuloendothelial system was normal, stimulated, or depressed.

Presence of receptors for polymerized albumin in HBsAg‐containing hepatocytes and hepatoma cell line

Swan N. Thung, Michael A. Gerber – 1 March 1981 – Recent evidence suggests that hepatitis B virions (HBV) and HBsAg particles contain receptors for polymerized human serum albumin (pHSA). We studied, by immunohistochemical techniques, the relationship between HBsAg and pHSA receptors in liver tissue from eight patients with chronic HBV infection and in a human hepatocellular carcinoma cell line (PLC/PRF/5) producing HBsAg. Both parallel sections and double fluorescent antibody staining of liver tissue demonstrated that only HBsAg‐containing hepatocytes expressed pHSA receptors.

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