Alcoholic liver disease: I. Interrelationships among histologic features and the histologic effects of prednisolone therapy

John K. Boitnott, Willis C. Maddrey – 1 November 1981 – Interrelationships among histologic features of alcoholic liver disease were studied in 24 chronic alcoholics who took part in a double‐blind, controlled trial of prednisolone vs. placebo therapy. Each patient underwent liver biopsy at the start and upon completion of the 1‐month study.

Globular hepatic amyloid–‐an unusual morphologic presentation

Gary C. Kanel, Toshikazu Uchida, Robert L. Peters – 1 November 1981 – Hepatic amyloid, when identified, is usually located in the sinusoids, portal tracts, and arterioles. We report 14 cases of hepatic amyloidosis where eosinophilic globules having the histochemical and electron microscopic features of classic amyloid were found. The globules were round to oval, 5 to 40 μm in diameter, and were found within the space of Disse as well as aggregated within the portal tracts.

Delayed HBsAg clearance in chronic hepatitis B viral infection

Karen L. Lindsay, Allan G. Redeker, Mary Ashcavai – 1 November 1981 – Seven patients are described in whom HBsAg persisted for 13 to 98 months after acute viral hepatitis B and then became nondetectable. All patients subsequently developed anti‐HBs. During the period of HBs‐antigenemia, liver biopsies in five patients showed persistent viral hepatitis. Retrospectively, impending negativity of HBsAg was predictable in five patients by a decrease in HBsAg titer, and in four patients by persistent normalization of serum alanine aminotransferase.

Membrane traffic at the hepatocyte's sinusoidal and canalicular surface domains

W. Howard Evans – 1 September 1981 – Traffic in the environs of regions of the hepatocyte's plasma membrane is heavy. A fuller understanding of the nature and control of this membrane traffic depends on the appreciation of the hepatocyte's plasma membrane. This conglomerate consists of a receptor‐rich and metabolically dynamic blood‐sinusoidal domain which is separated from the bile canalicular domain by a lateral domain which participates in cell‐cell interactions (1, 2).

Acute effects of ethanol on hepatic uptake and distribution of narcotics in the isolated perfused rabbit liver

Mary Jeanne Kreek, Marcus A. Rothschild, Murray Oratz, Joseph Mongelli, Anne C. Handley – 1 September 1981 – This study was performed as an initial step in systematically defining the hepatic interactions between ethanol and opioids using a controlled in vitro system. The acute effects of ethanol on the initial uptake and distribution of long‐ and short‐acting narcotics were studied using isolated rabbit liver perfused with rabbit blood without or with ethanol.

The hepatocellular uptake and biliary excretion of endotoxin in the rat

Shyamal K. Maitra, Daniel Rachmilewitz, David Eberle, Neil Kaplowitz – 1 September 1981 – Endotoxin is known to cause a dose‐dependent impairment of hepatic bile secretion, organic anion excretion, and activity of Na+, K+‐activated ATPase. Since it is possible that this impaired excretory function is a result of direct interaction of endotoxin with hepatocytes, we examined: (a) the excretion of endotoxin into bile, and (b) its association with an hepatocyte‐enriched, Kupffer cell‐depleted population of liver cells.

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