Effect of chronic alcohol intake on hepatic fibrosis and granulomas in marine schistosomiasis mansoni

Hector Orrego, Yedy Israel, Ian R. Crossley, Adel A. F. Mahmoud, Pierre A. Peters, George Varghese, Ian R. Wanless – 1 September 1981 – In consideration of the vast prevalence of schistosomiasis and heavy alcohol consumption in many parts of the world, the possibility of an interaction between these two conditions inducing liver disease was studied in mice infected with Schistosoma mansoni. Alcohol consumption significantly reduced by 25% the mean granuloma diameter and by about 60% the extent of fibrous tissue deposition determined chemically as hydroxyproline.

The risk of hepatitis B transmission from staff to patients in hemodialysis units–‐an overrated problem?

Douglas R. LaBrecque, Arun K. Dhand – 1 September 1981 – The staff and patients in hemodialysis units have the greatest hospital risk of acquiring hepatitis B (HB) infection. We followed the patients of two dialysis nurses in two different dialysis units. One nurse dialyzed 19 patients a total of 50 times during the prodrome of acute HB. The second nurse was a known, asymptomatic carrier of HBsAg who was also HBeAg(+) and anti‐HBc(+). Over a 2‐year period, she dialyzed 30 patients a total of 742 times.

Hepatitis B virus DNA in the sera of HBsAg carriers: A marker of active hepatitis B virus replication in the liver

Ferruccio Bonino, Bill Hoyer, Judith Nelson, Ronald Engle, Giorgio Verme, John Gerin – 1 September 1981 – Sera and liver biopsies from 30 Italian patients, carriers of HBsAg for at least 3 years, were examined for markers of hepatitis B virus (HBV) infection by serological assays and immunofluorescence. Biopsies were analyzed for HBcAg, HBsAg, and δ antigen by immunofluorescence; sera were assayed for HBsAg/anti‐HBs, HBcAg/anti‐HBc, HBeAg/anti‐HBe, δ/anti‐δ, HBV‐specific DNA polymerase activity and the presence of HBV DNA.

Muscle protein breakdown in liver cirrhosis and the role of altered carbohydrate metabolism

Giulio Marchesini, Marco Zoli, Angela Angiolini, Cristina Dondi, Francesco B. Bianchi, Emilio Pisi – 1 July 1981 – The rates of muscle protein breakdown, as estimated by the urinary excretion of 3‐methylhistidine, were assessed in 30 cirrhotics and 15 controls on a strictly controlled diet. 3‐Methylhistidine excretion was increased in cirrhotics irrespective of the etiology of the disease, and correlated with basal glucagon levels and with the insulin/glucagon ratio.

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