An Evaluation of Cellular Lineages in the Pathogenesis of Experimental Hepatocellular Carcinoma

Stewart Sell, Hyam L. Leffert – 1 January 1982 – Analysis of liver from rats exposed to chemical hepatocarcinogens has led to a model that postulates sequential premalignant changes, culminating in hepatoma formation from neoplastic nodules. Several experimental protocols devised during the last quarter century have focused upon this lineage model. But proof that neoplastic nodules are the definitive premalignant lesions has not been achieved.

The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat

Lorne E. Rotstein, Leonard Makowka, George Lee, Emmanuel Farber – 1 January 1982 – The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules.

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