Michael Manns, Karl‐Hermann Meyer, Zum Büschenfelde – 1 January 1982 – A radioimmunoassay (RIA) was established for the detection of antimitochondrial autoantibodies (AMAs) in patient sera. AMAs were detected by RIA in 12 of 14 patients with primary biliary cirrhosis and in 3 of 29 patients with chronic active hepatitis. AMAs were detected by indirect immunofluorescence in all sera positive by RIA.
Michael A. Dunn, Refaat Kamel – 1 November 1981
Jurgen Ludwig, Steven S. Barham, Nicholas F. Larusso, Lila R. Elveback, Russell H. Wiesner, John T. McCall – 1 November 1981 – Histologic, ultrastructural, chemical, and statistical methods were used to study liver biopsy and autopsy specimens from 43 patients who had primary sclerosing cholangitis (PSC), with or without chronic ulcerative colitis (CUC), and from 19 patients who had CUC without PSC. In all study groups, essentially the same abnormalities were found in the hepatic parenchyma outside the major bile ducts, although nondiagnostic tissue samples were observed also.
Sugantha Govindarajan, Mary Ashcavai, Robert L. Peters – 1 November 1981 – α‐1‐Antitrypsin deficiency due to homozygous Pi ZZ state is reported to be associated with cirrhosis and hepatocellular carcinoma (HCC); however, the role of heterozygous Pi Z state is not definitively known. In order to investigate the possible association, we studied the phenotypic distribution of α‐1‐antitrypsin variants (Pi) in 124 cases of HCC. Two thousand ten normal American Red Cross blood donors were studied as controls.
Dean J. Tuma, Richard B. Jennett, Michael F. Sorrell – 1 November 1981 – The effects of ethanol on the synthesis and secretion of serum glycoproteins and albumin, a nonglycosylated protein, were studied in rat liver slices. Serum glycoproteins and albumin were determined by immunoprecipitation from either the incubation medium or from the washed slices. When ethanol (10 mM) was present in the incubation medium, [14C]glucosamine incorporation in secretory glycoproteins was decreased.
Harold O. Conn – 1 November 1981
Ljudevit L. Andres, Vinod K. Sawhney, George H. Scullard, Joseph L. Smith, Thomas C. Merigan, William S. Robinson, Peter B. Gregory – 1 November 1981 – Fifty patients with chronic HBs antigenemia and Dane particle‐associated DNA polymerase and HBeAg in their serum were contrasted to 46 HBsAg positive patients who had neither serum DNA polymerase or HBeAg. The time from acute onset and the duration of antigenemia were longer in patients who were DNA polymerase and HBeAg negative than in those who had both serum markers.
Kunio Okuda – 1 November 1981
Julio Ponce, Agustin Froufe, Eduardo de la Morena, José Mir, Miguel Rayón, Ramón Pina, Joaquin Berenguer – 1 November 1981 – A morphometric study of the distal esophageal mucosa (within 5 cm above the gastroesophageal junction) has been carried out in a group of 11 cirrhotic patients undergoing esophageal transection with SPTU gun for variceal bleeding. The relative thickness of the papillae (62.2 ± 3.9%) and basal zone (11.8 ± 1.9%) were within normal limits. Polymorphonuclear infiltrates were not found either in the lamina propria or in the epithelium.