Susan J. Burwen, Albert L. Jones, Ira S. Goldman, Lawrence W. Way, Sussan Dejbakhsh – 1 July 1982 – We developed a simple and inexpensive method of perfusing small specimens of human liver in vitro that maintains short‐term tissue viability as judged by protein transport function and morphological features. The technique allows investigation of liver function at the cellular level in normal specimens and those with hepatobiliary disease.

David E. Hatoff, William G. M. Hardison – 1 July 1982 – The role of bile acids in the biliary secretion of alkaline phosphatase was studied. Rats with external bile fistulae were drained for 4 hr. After 2 hr, bile acid secretion fell progressively. Alkaline phosphatase secretion also decreased progressively during the period of drainage, suggesting that secretion of the two components was related. Each rat was then given an i.v. infusion of the taurine conjugate of either cholate, chenodeoxycholate, or ursodeoxycholate.

James H. Lewis, Hasmukh R. Patel, Hyman J. Zimmerman – 1 July 1982 – The liver is affected in up 50 to 75% of compromised hosts with disseminated Candida albicans infection who come to autopsy. The antemortem diagnosis of hepatic candidiasis is rarely made. Blood cultures are negative in approximately 50% of cases, and biochemical parameters of hepatic injury may be of nonspecific value. Additionally, the more commonly seen renal, cardiac, and respiratory involvement may overshadow the hepatic lesion.

1 July 1982

Bernard Nordlinger, Michel Parquet, Recaredo Infante, Reginald Moreels, Pol Blondiau, Michele Boschat, Michèle Groussard, Claude Huguet – 1 July 1982 – All of the methods proposed for measuring portal blood flow are either invasive, estimate total rather than nutrient flow, and none has proved reliable in cirrhotic patients. A method has been derived from pharmacokinetic principles used for the calculation of bioavailability of drugs according to the route of administration (i.v. or p.o.) and tested experimentally in 20 pigs.

Douglas R. Labrecque, Frank A. Mitros, Radha J. Nathan, Ken G. Romanchuk, George F. Judisch, George H. El‐Khoury – 1 July 1982 – Arteriohepatic dysplasia (AHD) is a multisystem disorder which is characterized by liver, heart, eye, and bony abnormalities. A characteristic facies is also present. The etiology is not clear, and some authors have favored an in utero toxin or infection as the cause. Other reports have shown parent‐to‐child transmission suggesting an autosomal dominant form of inheritance.

Howard A. Liebman, Barbara C. Furie, Bruce Furie – 1 July 1982

John C. Hoefs, Hanna N. Canawati, Francisco L. Sapico, R. Randy Hopkins, John Weiner, John Z. Montgomerie – 1 July 1982 – Forty‐three patients with spontaneous bacterial peritonitis (SBP) between 1973 and 1978 were identified. Criteria for SBP included a positive ascites culture and polymorphonuclear cell concentration greater than 250 cells per mm3. Chronic liver disease was documented by varices in 91%, severe histologic fibrosis or cirrhosis in 94%, splenomegaly in 91%, and past hospitalization for liver disease in 57% of the patients.

Harold O. Conn – 1 July 1982

Dale A. Schoeller, Alfred L. Baker, Paul S. Monroe, Patricia S. Krager, John F. Schneider – 1 July 1982 – Different methods of expressing the results of the aminopyrine C02 breath test (ABT) were compared to determine the method that would be most sensitive for evaluating liver function.