Ronald E. Kleinman, Paul R. Harmatz, W. Allan Walker – 1 May 1982

Paul S. Monroe, Alfred L. Baker, John F. Schneider, Patricia S. Krager, Peter D. Klein, Dale Schoeller – 1 May 1982 – To determine whether the aminopyrine breath test (ABT) and serum bile acid concentrations reflect histologic severity of chronic hepatitis, 56 patients were prospectively evaluated with liver biopsies and ABTs, and the results were compared to results of standard liver chemistry tests; 44 of these patients also had fasting and 2‐hr postprandial serum bile acid measurements.

Masayasu Inoue, Kenji Okajima, Yoshimasa Morino – 1 May 1982 – When S‐carbamido(14C)methyl glutathione, a model compound of glutathione S‐conjugate, was administered i.v. to mice, radioactivity accumulated in the kidney within 1 to 2 min and then decreased gradually during the following 10 to 15 min with concomitant increase in hepatic radioactivity. Most hepatic radioactivity was accounted for by S‐carbamidomethyl cysteine and its N‐acetyl derivative, a mercapturic acid. The i.v.

Esteban Mezey, James J. Potter – 1 May 1982 – Castration was previously demonstrated to result in an increase in liver alcohol dehydrogenase and in rates of ethanol elimination in male rats. In this study, the effect of dihydrotestosterone, which is a more potent androgen than testosterone in the rat, was determined on liver alcohol dehydrogenase and ethanol elimination in the castrated rat. Dihydrotestosterone was found to be a substrate of liver alcohol dehydrogenase in the reductive direction and a competitive inhibitor of ethanol oxidation by the enzyme.

Beverly Barrett Dahms, Mary Petrelli, Robert Wyllie, Malcolm S. Henoch, Thomas C. Halpin, Stuart Morrison, Moonja Chung Park, Anthony S. Tavill – 1 May 1982 – Arteriohepatic dysplasia (syndromatic ductular hypoplasia, Alagille syndrome) is a condition of chronic cholestasis dating from infancy accompanied by characteristic facies, pulmonic stenosis, and other somatic abnormalities. The pathologic hallmark of arteriohepatic dysplasia is a paucity or absence of intrahepatic bile ducts, wildely regarded as a congenital deficiency.

1 May 1982

1 May 1982

George W. Mihaly, Denis J. Morgan, Richard Smallwood, Kenneth J. Hardy – 1 May 1982 – The steady‐state disposition of the β‐adrenoreceptor blocking drug, propranolol, and its metabolite, 4‐hydroxypropranolol, was studied in the anesthetized pregnant sheep near term. Following infusion of propranolol to the mother, steady‐state plasma concentrations were obtained at three dosage levels in each of the eight animals studied. Blood samples were obtained from: (i) maternal facial artery and hepatic vein; (ii) umbilical vein, and (iii) fetal carotid artery, portal vein, and right hepatic vein.

Mauro Podda, Massimo Zuin, Maria L. Dioguardi, Susanna Festorazzi, Nicola Dioguardi – 1 May 1982 – The effects on biliary lipids of 10 mg per kg per day of chenodeoxycholic acid (CDCA), 10 mg per kg per day of ursodeoxycholic acid (UDCA), and their equimolar combination (5 mg per kg per day of each), all administered for 45 to 60 days, were investigated in 18 patients with gallstones in a double‐blind study with a balanced latin square design.

Helmer Ring‐Larsen, Birger Hesse, Jens H. Henriksen, Niels J. Christensen – 1 May 1982 – Systemic and renal neurovascular reactivity was investigated in eight patients with cirrhosis and in eight control subjects with fatty liver during postural changes. In the supine position, mean renal blood flow averaged 1.51 and 2.97 ml per gm per min in patients and controls, respectively (p < 0.02).