Bernard Nordlinger, Michel Parquet, Recaredo Infante, Reginald Moreels, Pol Blondiau, Michele Boschat, Michèle Groussard, Claude Huguet – 1 July 1982 – All of the methods proposed for measuring portal blood flow are either invasive, estimate total rather than nutrient flow, and none has proved reliable in cirrhotic patients. A method has been derived from pharmacokinetic principles used for the calculation of bioavailability of drugs according to the route of administration (i.v. or p.o.) and tested experimentally in 20 pigs.

1 July 1982

James H. Lewis, Hasmukh R. Patel, Hyman J. Zimmerman – 1 July 1982 – The liver is affected in up 50 to 75% of compromised hosts with disseminated Candida albicans infection who come to autopsy. The antemortem diagnosis of hepatic candidiasis is rarely made. Blood cultures are negative in approximately 50% of cases, and biochemical parameters of hepatic injury may be of nonspecific value. Additionally, the more commonly seen renal, cardiac, and respiratory involvement may overshadow the hepatic lesion.

David E. Hatoff, William G. M. Hardison – 1 July 1982 – The role of bile acids in the biliary secretion of alkaline phosphatase was studied. Rats with external bile fistulae were drained for 4 hr. After 2 hr, bile acid secretion fell progressively. Alkaline phosphatase secretion also decreased progressively during the period of drainage, suggesting that secretion of the two components was related. Each rat was then given an i.v. infusion of the taurine conjugate of either cholate, chenodeoxycholate, or ursodeoxycholate.

Susan J. Burwen, Albert L. Jones, Ira S. Goldman, Lawrence W. Way, Sussan Dejbakhsh – 1 July 1982 – We developed a simple and inexpensive method of perfusing small specimens of human liver in vitro that maintains short‐term tissue viability as judged by protein transport function and morphological features. The technique allows investigation of liver function at the cellular level in normal specimens and those with hepatobiliary disease.

Richard A. Weisiger – 1 July 1982

Marcel Patterson, Juan C. Gonzalez‐Vitale, Charles J. Fagan – 1 July 1982 – Cyst fluid from a patient with polycystic liver disease was obtained by needle aspiration using ultrasound guidance. The constituents of the fluid resembled the “bile salt‐independent” fraction of human bile and supports the hypothesis that such cysts are lined by a functioning, secretory bile duct epithelium.

David B. Flannery, Y. Edward Hsia, Barry Wolf – 1 July 1982

Giulio Marchesini, Marco Zoli, Cristina Dondi, Giampaolo Bianchi, Maurizio Cirulli, Emilio Pisi – 1 July 1982 – An amino acid mixture rich in branched‐chain amino acids and poor in aromatic amino acids was infused in six cirrhotics with altered plasma amino acid profile and normal mental state. The effect on muscle protein catabolism, as measured by urinary excretion of 3‐methylhistidine, was assessed during two consecutive 3‐day periods in which patients received the amino acid mixture alone or in a hypertonic dextrose solution.

Norman Gitlin, John L. Stauffer, Ronald C. Silvestri – 1 July 1982 – Fifty‐six patients with alcoholic cirrhosis and ascites were studied. The ascitic fluid was analyzed for pH, PO PCO2, glucose, protein, specific gravity, amylase, lactic dehydrogenase, white blood cell count, polymorphonuclear count, and cytology. It was also cultured aerobically and anaerobi‐cally. Simultaneously, arterial blood was analyzed for pH, PO2, and PCO2. Venous blood was analyzed for complete blood count, protein, aspartate transaminase, and it was also cultured under aerobic and anaerobic conditions.