Bruno Voss, Jürgen Rauterberg, Gerhard Pott, Ute Brehmer, Salah Allam, Rolf Lehmann, Dirk B. V. Bassewitz – 1 January 1982 – Tissue specimens from human fibrotic liver obtained by needle biopsy were cultured. Two cell types emerged from the tissue explants. From their morphology and biosynthetic products they resembled smooth muscle cells and endothelial cells from blood vessel walls. In the “endothelial” cells, factor VIII‐associated protein was demonstrated by indirect immunofluorescence.

Peter Kryger, Jan Aldershvile, Lars R. Mathiesen, Jens O. Nielsen, The Copenhagen Hepatitis Acuta Programme – 1 January 1982 – A consecutive group of 169 patients with acute hepatitis found negative for hepatitis B surface antigen (HBsAg) and negative for IgM antibody against hepatitis A (anti‐HAV IgM) was studied for presence of IgM antibody against hepatitis B core antigen (anti‐HBc IgM) by ELISA. Anti‐HBc IgM was found in a total of 34 of 60 patients with detectable total anti‐HBc.

Robert A. Branch – 1 January 1982 – It is well recognized that liver disease may influence the disposition of many drugs. Conversely, it has been suggested that knowledge of the disposition of a model drug might provide an index of certain aspects of hepatic function. This review discusses the physiology of drug disposition and indicates how recent progress in understanding the determinants of drug disposition has provided useful indices of individual aspects of hepatic function.

David A. Shafritz, Irwin M. Arias – 1 January 1982

Scheffer C. G. Tseng, Philip C. Lee, Peter F. Ells, D. Montgomery Bissell, Edward A. Smuckler, Robert Stern – 1 January 1982 – The cellular sources of collagen in normal rat liver have been examined. Hepatocytes and nonparenchymal (sinusoidal) cells were isolated and established in primary monolayer culture. These cells were incubated with radiolabeled proline in the presence of L‐ascorbate and β‐amino‐propionitrile. Nondialyzable material was prepared from the cell layer and the medium from each type of culture.

George H. Scullard, Harry B. Greenberg, Joseph L. Smith, Peter B. Gregory, Thomas C. Merigan, William S. Robinson – 1 January 1982 – Fourteen chimpanzees were inoculated with pre‐ and posttreatment sera from seven patients with persistent hepatitis B virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside.

Marc Goldman, Z. Reno Vlahcevic, Charles C. Schwartz, Jan Gustafsson, Leon Swell – 1 January 1982 – In order to evaluate more definitively the observed aberrations in the synthesis of cholic and chenodeoxycholic acids in patients with advanced cirrhosis, two bile acid biosynthesis pathways were examined by determining the efficiency of conversion of [3H]7α‐hydroxycholesterol and [3H] 26‐hydroxycholesterol to primary bile acids. Bile acid kinetics were determined by administration of [14C]cholic and [14C]chenodeoxycholic acids.

1 January 1982

1 January 1982

Samuel W. French, Isao Kondo, Tetsuya Irie, Thomas J. Ihrig, Nancy Benson, Robert Munn – 1 January 1982 – Rat livers perfused with 0.5% Triton X‐100 for 15 to 90 min followed by 1% sodium dodecyl sulfate for 30 min were studied by electron microscopy and polyaerylamide gel electrophoresis. After 15 min of perfusion, a rich network of intermediate filaments and microtubules was visualized in the cytoplasm of hepatocytes. Using stereopairs, branching was visualized. Connections of filaments were noted with nuclei, centrioles, microtubules, vesicles, and rough endoplasmic reticulum.