Acetaminophen‐induced fulminant hepatic failure in Dogs

L. Ortega, J. I. Landa Garcia, A. Torres Garcia, G. Silecchia, J. Arenas, A. Suarez, M. Moreno Azcoitia, J. Sanz Esponera, E. Moreno Gonzalez, J. L. Balibrea Cantero – 1 July 1985 – Results concerning morphological and biochemical changes following intravenous administration of different doses of acetaminophen in dogs are reported. Acetaminophen infusion, as a parenteral solution (500 mg per kg per 90 min), produced fulminant hepatitis characterized by a good correlation between Portmann's grade of lesion and percentage of necrosis. All animals died within 76 hr after intoxication.

Effects of ioglycamide on the hepatic transport of bilirubin and its mono‐ and diconjugates in the rat

Vital A. Mesa, Johan Fevery, Karel P. M. Heirwegh, Jan De Groote – 1 July 1985 – Bilirubin seems to share the biliary excretion pathway with other organic anions, but not with bile acids. We studied the effects of the organic anion ioglycamide, an iodinated contrast agent, on bilirubin metabolism in Wistar rats. This compound does not undergo conjugation and is characterized by a maximal biliary secretory rate (Tm).

Recombinant leukocyte interferon treatment of chronic hepatitis B

Geoffrey Dusheiko, Adrian Dibisceglie, Sheila Bowyer, Evelyn Sachs, Marian Ritchie, Barry Schoub, Michael Kew – 1 July 1985 – We have investigated the efficacy of a relatively prolonged course of recombinant leukocyte interferon treatment in 14 chronic HBsAg‐, HBeAg‐, hepatitis B virus DNA‐ and DNA polymerase‐positive carriers. α‐Interferon was administered for 9 weeks. Six of 14 treated carriers have a sustained loss of HBeAg, hepatitis B virus DNA and DNA polymerase. Four subsequently lost HBsAg (28.5%).

Effect of systemic pH, PCO2 and bicarbonate concentration on biliary bicarbonate secretion in the rat

Michèle Corbic, Cristina Muñoz, Micheline Dumont, Ghislaine De Couët, Serge Erlinger – 1 July 1985 – The effect of acute metabolic or respiratory acid‐base disturbances on biliary bicarbonate secretion was examined in bile fistula rats. Animals were infused with ursodeoxycholate at a rate that stimulates bicarbonate secretion (1 μmole · min−1 · 100 gm−1), in control conditions and during acute acid‐base disturbances.

The spectrum of complement‐fixing antinuclear antibodies in patients with hepatocellular carcinoma

Kendo Kiyosawa, Richard J. Daemer, Li‐Fang He, Ferruccio Bonino, O. W. Prozesky, Robert H. Purcell – 1 July 1985 – Sera from 230 hepatocellular carcinoma patients were tested for antinuclear antibodies by anticomplement immunofluorescence in 16 types of transformed, diploid or primary cells of human, monkey, chimpanzee or rat origin. As controls, we tested 85 sera from patients with chronic liver diseases, 48 sera from patients with nonhepatic cancers and 164 sera of normal controls.

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