Robert H. , Fennell Jr, Robert H. Shikes, John M. Vierling – 1 January 1983 – Histopathological features of nonsuppurative destructive cholangitis have been described in primary biliary cirrosis, chronic graft‐vs.‐host disease, and chronic rejection of human liver allografts. To determine whether or not susceptibility to injury of interlobular bile ducts was related to the original hepatobiliary disease requiring transplantation, we compared the histopathology of allografts transplanted into two groups of patients.

Bruce W. Trotman, Michael B. Bongiovanni, Marc J. Kahn, Seldon E. Bernstein – 1 November 1982 – The nb/nb mouse with a hereditary hemolytic anemia is an animal model of hemolysis‐induced gallstone disease. These anemic mice have hepatomegaly and form calcium bilirubinate gallstones. We undertook this study to: (a) examine the histopathology of the liver and gallbladder in nb/nb mice and (b) assess the influence of hemolysis per se on liver and gallbladder histology by transplanting nb/nb bone marrow into another genotype W/Wv.

J. Pinto Correia, L. Bívar, A. M. Bívar – 1 November 1982

Alessandro Trevisan, Fred Gudat, Richard Guggenheim, Gunthild Krey, Ursula Dürmüller, Guido Lüond, Marcel Düggelin, Jonas Landmann, Pietro Tondelli, Leonardo Bianchi – 1 November 1982 – The presence of albumin receptors on the plasma membrane of isolated human hepatocytes was investigated employing albumin‐coupled latex minibeads. Hepatocyte‐latex reaction was visualized by phase contrast and scanning electron microscopy.

Ashok K. Batta, Gerald Salen, Sarah Shefer, G. Steven Tint, Bishambar Dayal – 1 November 1982 – The biliary bile acid conjugation patterns were determined by high‐performance liquid chromatography in five subjects after 6 months of 500 mg per day of free ursodeoxycholic acid feeding. Prior to bile acid therapy, approximately 35% of the biliary bile acids were conjugated with taurine and approximately 65% were glycine conjugated, and ursodeoxycholic acid was either absent or, when present, accounted for less than 5% as the glycine conjugate.

Yasuhiro Kato, Hirohito Nakagawa, Kenichi Kobayashi, Nobu Hattori, Kiichi Hatano – 1 November 1982 – Interferon production by lymphocytes was normal in HBsAg carriers with normal liver function tests and normal liver histology, whereas it was significantly decreased in HBsAg‐positive patients with chronic active hepatitis and cirrhosis. It is possible that an impaired interferon system is causally related to the development of chronic liver disease in hepatitis B virus infection.

1 November 1982

Matthew S. Loewenstein – 1 November 1982

James H. Lewis, Hyman J. Zimmerman, Carlton T. Garrett, Elliot Rosenberg – 1 November 1982 – The administration of high‐dose valproic acid (VPA) (750 mg per kg) consistently produced significant microvesicular steatosis in mature Sprague‐Dawley rats after 48 hr. Similar changes occurred in animals pretreated with phenobarbital which received a lower dose of VPA (350 mg per kg), but no steatosis was seen in animals treated with the low‐dose VPA alone. The steatogenic effect of VPA is most likely mediated by a toxic metabolite.

George W. Mihaly, Richard A. Smallwood, Jeanette D. Anderson, D. Brian Jones, Lorraine K. Webster, Frank J. Vajda – 1 November 1982 – The effect of four H2‐receptor antagonists (Cimetidine, burimamide, oxmetidine, and ranitidine) on antipyrine elimination was studied in the isolated perfused rat liver. The first three drugs are substituted imidazoles, whereas ranitidine contains a furanyl nucleus. Isolated livers were perfused using a 100‐ml, recycling, constant flow circuit for 4 hr. Antipyrine elimination was studied with or without an H2‐receptor antagonist present.