Gabriele E. Schrempf‐Decker, Diethard P. Baron, Norbert W. Brattig, Hermann Bockhorn, Peter A. Berg – 1 January 1983 – The liver immunoregulatory protein (LIP) was originally characterized as human liver‐derived soluble factor which inhibited the alloantigen and phytohemagglutinin‐induced proliferation of human lymphocytes (1). Soluble extracts prepared under the same experimental conditions from kidney, spleen, heart, lymph nodes, and erythrocytes did not exert any inhibitory activity (2). The purpose of this study was to characterize the immunobiological properties of LIP.

John E. Hegarty, Kayhan T. Nouri Aria, Bernard Portmann, Adrian L. W. F. Eddleston, Roger Williams – 1 January 1983 – A prospective study was performed to evaluate the outcome of treatment withdrawal in 30 patients with “autoimmune” chronic active hepatitis in remission for periods of 1.5 to 9 years on maintenance corticosteroid and azathioprine therapy. Reactivation of disease, with marked rises in serum aminotransferase level (mean 668 ± S.D.

William V. Mcdermott – 1 January 1983

Clyde Crumpacker – 1 January 1983

Sten Eriksson, Christer Larsson – 1 January 1983 – Three of four adult siblings in a family which was studied for three generations had clinical and/ or laboratory signs of slowly progressive intrahepatic cholestasis. Slight hyper pigmentation, facial hypertrichosis, and hypothyroidism were seen in affected individuals who also had prolonged increase in serum transaminase, γ‐glutamyltranspeptidase, and alkaline phosphatase activities.

William G. M. Hardison, Robin G. Weiner, David E. Hatoff, Katsumi Miyai – 1 January 1983 – Biliary obstruction in the rat causes known biochemical and morphological abnormalities. These abnormalities might be caused simply by retention of biliary constituents or might require other factors such as high biliary pressure, interruption of the normal flux of fluid, ions, and other biliary constituents through the hepatocyte and/or changes in intracellular concentrations, binding, and distribution of biliary constituents.

Gary C. Kanel, George Radvanand, Robert L. Peters – 1 January 1983 – To establish whether there is any significant relationship between high‐density lipoprotein cholesterol (HDLC) concentrations and biopsy‐documented liver disease, 169 patients had needle biopsies, serum cholesterol, and HDLC evaluated. Twenty‐four patients had serial cholesterol, HDLC, prothrombin, and aminotransferase levels and activities examined. In both men and women, HDLC decreased strikingly and significantly in acute alcoholic hepatitis and in acute viral hepatitis, compared to controls (p < 0.001).

Geoffrey Dusheiko, Ernest Song, Sheila Bowyer, Michael Whitcutt, Gunthild Maier, Anthony Meyers, Mlchael C. Kew – 1 January 1983 – Hepatitis B virus (HBV) markers were measured in 83 immunosuppressed renal transplant patients who were followed for periods of 2 to 15 years. Sixty‐nine patients were negative for HBsAg before transplantation, of whom 14 were positive for anti‐HBs. The remaining 14 patients were HBsAg positive prior to transplantation. Eighteen patients were identified as being HBsAg positive during the follow‐up period.

Marisabel Mourelle, Javier Cordero‐Hernández, Patricia Ponce‐Noyola, Marcos Rojkind – 1 January 1983 – Liver biomatrix contains a group of connective tissue components needed for attachment, survival, and maintenance of liver‐specific functions of adult rat hepatocytes in culture. An acidic extract of liver biomatrix that contains a group of glycoproteins can replace intact biomatrix in promoting attachment and survival of hepatocytes. However, except for albumin synthesis, liver‐specific functions have not been tested.

Charles S. Davidson – 1 January 1983