Measurement of Serum α1‐Acid Glycoprotein and cei‐Antitrypsin Desialylation in Liver Disease

Nathalie Serbource‐Goguel, Michèle Corbic, Serge Erlinger, Geneviève Durand, Jean Agneray, Jeanne Feger – 1 January 1983 – To determine whether the presence of circulating desialylated glycoproteins reflect the existence and/or the severity of liver disease, 73 patients were evaluated with liver biopsies, conventional liver function tests, and the measurement of the degree of desialylation of two glycoproteins ax‐acid glycoprotein (α1‐AGP) and ai‐antitrypsin (α1‐AT).

Development and Use of a Rat Albumin cDNA Clone to Evaluate the Effect of Chronic Ethanol Administration on Hepatic Protein Synthesis

Mark A. Zern, Prasanta R. Chakraborty, Nelson Ruiz‐Opazo, Sing H. Yap, David A. Shafritz – 1 January 1983 – A rat albumin cDNA probe (pBR alb 149) was developed in order to investigate the molecular mechanisms responsible for changes in hepatic protein synthesis after chronic administration of ethanol to rats. Rats fed a diet for up to 1 year in which 36% of calories were from ethanol, developed fatty livers but not cirrhosis.

Radioimmunoassay of Human Ligandin

Morris Sherman, Nathan M. Bass, John A. H. Campbell, Ralph E. Kirsch – 1 January 1983 – A sensitive and specific radioimmunoassay for human ligandin has been developed and used to study ligandin release into the serum in acute and chronic hepatitis. Serum ligandin concentrations were elevated in 67 of 68 cases of acute viral hepatitis. Ligandin levels frequently returned to normal within the first 2 weeks of illness. The rapid disappearance of ligandin preceded the return to normal of serum SGOT.

Hepatocyte Membrane‐Bound IgG and Circulating Liver‐Specific Autoantibodies in Chronic Liver Disease: Relation to Hepatitis B Virus Serum Markers and Liver Histology

Riccardo Meliconi, Federico Miglio, M. Valeria Stancari, Mario Baraldini, G. Francesco Stefanini, Giovanni Gasbarrini – 1 January 1983 – Hepatocytes isolated from 101 biopsies were examined for membrane‐bound IgG. The sera of the patients were tested for anti‐liver‐specific lipoprotein by radioimmunoassay and for liver membrane autoantibody (by indirect immunofluorescence on isolated rabbit hepatocytes. The seven patients with normal liver or minor nonspecific alterations were negative for membrane IgG and serum antibodies.

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