Briefly Noted. Transmembrane Signaling. Proceedings of the ICN‐UCLA Symposium, Keystone, Colorado, February 26‐March 3,1978. Edited by M. Bitensky, R. J. Collier, D. F. Steiner, and C. F. Fox. New York: Liss, 1979. $94.00.

Liver Transplantation in Adults

David H. Van Thiel, Robert R. Schade, Thomas E. Starzl, Shunzaburo Iwatsuki, Byers W. , Shaw Jr ., Judith S. Gavaler, Marcus Dugas – 1 September 1982 – Human liver transplantation has been possible since 1967. We report our experience in 32 adult patients who received liver transplants at the University of Pittsburgh over a 16‐month period. Survival data, method utilized for patient selection, costs, and morbidity of the procedure are discussed.

The Role of Hepatocyte Enlargement in Hepatic Pressure in Cirrhotic and Noncirrhotic Alcoholic Liver Disease

Laurence M. Blendis, Hector Orrego, Ian R. Crossley, Joan E. Blake, Alan Medline, Yedy Israel – 1 September 1982 – The relationship between hepatocyte enlargement and intrahepatic and portal pressures was studied in a group of 163 patients with alcoholic liver disease presenting liver biopsy abnormalities, including 91 cirrhotics. For the complete group, hepatocyte surface areas were significantly correlated (r = 0.73, p < 0.0001) with pressure. Cirrhotics as a group had a mean average pressure of 20.4 ± 0.9 mm Hg, while that for noncirrhotics was 11.7 ± 0.8 mm Hg (p < 0.0001).

Visual Evoked Potentials in Encephalopathy Induced by Galactosamine, Ammonia, Dimethyldisulfide, and Octanoic Acid

Maria L. Zeneroli, Ezio Ventura, Mario Baraldi, Alessandro Penne, Elena Messori, Leslie Zieve – 1 September 1982 – Visual evoked potentials were utilized to examine the neuronal transmission changes provoked by galactosamine‐induced hepatic encephalopathy and by administration in normal animals of toxins presumably involved in the pathogenesis of hepatic encepalopathy.

Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport

Masayasu Inoue, Rolf Kinne, Thao Tran, Irwin M. Arias – 1 September 1982 – To elucidate the first step in the vectorial transport of bile acids by the liver, plasma membrane vesicles were isolated from rat liver by differential and sucrose‐Ficoll density gradient centrifugation. The membranes were selectively enriched 20‐fold in Na+,K+−ATPase activity, a marker of sinusoidal plasma membranes. Electron microscopy of pellets from sinusoidal membrane fraction did not reveal other organelles.

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