Giovanni Raimondo, Serafino Recchia, Carla Lavarini, Osvaldo Crivelli, Mario Rizzetto – 1 July 1982 – A commercial radioimmunoassay was adapted to detect serum Dane particle‐associated HBeAg in patients whose sera contained the homologous antibody. HBeAg was released from Dane particles with guanidine HC1.

Zachary D. Goodman, Kamal G. Ishak – 1 July 1982 – To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as “fibrolamellar” carcinoma. This subtype of HCC occurs predominantly in young people, both male and female.

1 July 1982

Humberto Reyes, María E. Wegmann, Nelly Segovia, Miguel Cuchacovich, Enrique Jadresic, Mónica Contador, Cecilia Fuentes, Mireya Melendez – 1 July 1982 – A possible association between intrahepatic cholestasis of pregnancy (ICP) and human‐leukocyte histocompatibility (HLA) antigens–used as genetic markers–was studied in 100 women with ICP compared to 100 multiparous women without a past history of the disease. Because we previously found a higher frequency of ICP in women with an overt Araucanian Indian descent than in Chilean Caucasoids, women from both ethnic groups were studied.

Kurt Jungermann, Norbert Katz – 1 May 1982 – Hepatocytes from the periportal (afferent) and perivenous (efferent) zones of the liver parenchyma differ in their enzyme content and subcellular structures.

Ronald E. Kleinman, Paul R. Harmatz, W. Allan Walker – 1 May 1982

Paul S. Monroe, Alfred L. Baker, John F. Schneider, Patricia S. Krager, Peter D. Klein, Dale Schoeller – 1 May 1982 – To determine whether the aminopyrine breath test (ABT) and serum bile acid concentrations reflect histologic severity of chronic hepatitis, 56 patients were prospectively evaluated with liver biopsies and ABTs, and the results were compared to results of standard liver chemistry tests; 44 of these patients also had fasting and 2‐hr postprandial serum bile acid measurements.

Masayasu Inoue, Kenji Okajima, Yoshimasa Morino – 1 May 1982 – When S‐carbamido(14C)methyl glutathione, a model compound of glutathione S‐conjugate, was administered i.v. to mice, radioactivity accumulated in the kidney within 1 to 2 min and then decreased gradually during the following 10 to 15 min with concomitant increase in hepatic radioactivity. Most hepatic radioactivity was accounted for by S‐carbamidomethyl cysteine and its N‐acetyl derivative, a mercapturic acid. The i.v.

Esteban Mezey, James J. Potter – 1 May 1982 – Castration was previously demonstrated to result in an increase in liver alcohol dehydrogenase and in rates of ethanol elimination in male rats. In this study, the effect of dihydrotestosterone, which is a more potent androgen than testosterone in the rat, was determined on liver alcohol dehydrogenase and ethanol elimination in the castrated rat. Dihydrotestosterone was found to be a substrate of liver alcohol dehydrogenase in the reductive direction and a competitive inhibitor of ethanol oxidation by the enzyme.

Beverly Barrett Dahms, Mary Petrelli, Robert Wyllie, Malcolm S. Henoch, Thomas C. Halpin, Stuart Morrison, Moonja Chung Park, Anthony S. Tavill – 1 May 1982 – Arteriohepatic dysplasia (syndromatic ductular hypoplasia, Alagille syndrome) is a condition of chronic cholestasis dating from infancy accompanied by characteristic facies, pulmonic stenosis, and other somatic abnormalities. The pathologic hallmark of arteriohepatic dysplasia is a paucity or absence of intrahepatic bile ducts, wildely regarded as a congenital deficiency.