Lorne E. Rotstein, Leonard Makowka, George Lee, Emmanuel Farber – 1 January 1982 – The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules.

1 January 1982

1 January 1982

Samuel W. French, Isao Kondo, Tetsuya Irie, Thomas J. Ihrig, Nancy Benson, Robert Munn – 1 January 1982 – Rat livers perfused with 0.5% Triton X‐100 for 15 to 90 min followed by 1% sodium dodecyl sulfate for 30 min were studied by electron microscopy and polyaerylamide gel electrophoresis. After 15 min of perfusion, a rich network of intermediate filaments and microtubules was visualized in the cytoplasm of hepatocytes. Using stereopairs, branching was visualized. Connections of filaments were noted with nuclei, centrioles, microtubules, vesicles, and rough endoplasmic reticulum.

1 January 1982

1 January 1982

Marc Goldman, Z. Reno Vlahcevic, Charles C. Schwartz, Jan Gustafsson, Leon Swell – 1 January 1982 – In order to evaluate more definitively the observed aberrations in the synthesis of cholic and chenodeoxycholic acids in patients with advanced cirrhosis, two bile acid biosynthesis pathways were examined by determining the efficiency of conversion of [3H]7α‐hydroxycholesterol and [3H] 26‐hydroxycholesterol to primary bile acids. Bile acid kinetics were determined by administration of [14C]cholic and [14C]chenodeoxycholic acids.

George H. Scullard, Harry B. Greenberg, Joseph L. Smith, Peter B. Gregory, Thomas C. Merigan, William S. Robinson – 1 January 1982 – Fourteen chimpanzees were inoculated with pre‐ and posttreatment sera from seven patients with persistent hepatitis B virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside.

Scheffer C. G. Tseng, Philip C. Lee, Peter F. Ells, D. Montgomery Bissell, Edward A. Smuckler, Robert Stern – 1 January 1982 – The cellular sources of collagen in normal rat liver have been examined. Hepatocytes and nonparenchymal (sinusoidal) cells were isolated and established in primary monolayer culture. These cells were incubated with radiolabeled proline in the presence of L‐ascorbate and β‐amino‐propionitrile. Nondialyzable material was prepared from the cell layer and the medium from each type of culture.

David A. Shafritz, Irwin M. Arias – 1 January 1982