Arteriohepatic Dysplasia in Infancy and Childhood: A Longitudinal Study of Six Patients

Beverly Barrett Dahms, Mary Petrelli, Robert Wyllie, Malcolm S. Henoch, Thomas C. Halpin, Stuart Morrison, Moonja Chung Park, Anthony S. Tavill – 1 May 1982 – Arteriohepatic dysplasia (syndromatic ductular hypoplasia, Alagille syndrome) is a condition of chronic cholestasis dating from infancy accompanied by characteristic facies, pulmonic stenosis, and other somatic abnormalities. The pathologic hallmark of arteriohepatic dysplasia is a paucity or absence of intrahepatic bile ducts, wildely regarded as a congenital deficiency.

Effect of Dihydrotestosterone on Rat Liver Alcohol Dehydrogenase Activity

Esteban Mezey, James J. Potter – 1 May 1982 – Castration was previously demonstrated to result in an increase in liver alcohol dehydrogenase and in rates of ethanol elimination in male rats. In this study, the effect of dihydrotestosterone, which is a more potent androgen than testosterone in the rat, was determined on liver alcohol dehydrogenase and ethanol elimination in the castrated rat. Dihydrotestosterone was found to be a substrate of liver alcohol dehydrogenase in the reductive direction and a competitive inhibitor of ethanol oxidation by the enzyme.

Metabolic Coordination of Liver and Kidney in Mercapturic Acid Biosynthesis In Vivo

Masayasu Inoue, Kenji Okajima, Yoshimasa Morino – 1 May 1982 – When S‐carbamido(14C)methyl glutathione, a model compound of glutathione S‐conjugate, was administered i.v. to mice, radioactivity accumulated in the kidney within 1 to 2 min and then decreased gradually during the following 10 to 15 min with concomitant increase in hepatic radioactivity. Most hepatic radioactivity was accounted for by S‐carbamidomethyl cysteine and its N‐acetyl derivative, a mercapturic acid. The i.v.

The Aminopyrine Breath Test and Serum Bile Acids Reflect Histologic Severity in Chronic Hepatitis

Paul S. Monroe, Alfred L. Baker, John F. Schneider, Patricia S. Krager, Peter D. Klein, Dale Schoeller – 1 May 1982 – To determine whether the aminopyrine breath test (ABT) and serum bile acid concentrations reflect histologic severity of chronic hepatitis, 56 patients were prospectively evaluated with liver biopsies and ABTs, and the results were compared to results of standard liver chemistry tests; 44 of these patients also had fasting and 2‐hr postprandial serum bile acid measurements.

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