Robert A. Branch – 1 January 1982 – It is well recognized that liver disease may influence the disposition of many drugs. Conversely, it has been suggested that knowledge of the disposition of a model drug might provide an index of certain aspects of hepatic function. This review discusses the physiology of drug disposition and indicates how recent progress in understanding the determinants of drug disposition has provided useful indices of individual aspects of hepatic function.

Peter Kryger, Jan Aldershvile, Lars R. Mathiesen, Jens O. Nielsen, The Copenhagen Hepatitis Acuta Programme – 1 January 1982 – A consecutive group of 169 patients with acute hepatitis found negative for hepatitis B surface antigen (HBsAg) and negative for IgM antibody against hepatitis A (anti‐HAV IgM) was studied for presence of IgM antibody against hepatitis B core antigen (anti‐HBc IgM) by ELISA. Anti‐HBc IgM was found in a total of 34 of 60 patients with detectable total anti‐HBc.

Bruno Voss, Jürgen Rauterberg, Gerhard Pott, Ute Brehmer, Salah Allam, Rolf Lehmann, Dirk B. V. Bassewitz – 1 January 1982 – Tissue specimens from human fibrotic liver obtained by needle biopsy were cultured. Two cell types emerged from the tissue explants. From their morphology and biosynthetic products they resembled smooth muscle cells and endothelial cells from blood vessel walls. In the “endothelial” cells, factor VIII‐associated protein was demonstrated by indirect immunofluorescence.

Stanley J. Wolfe – 1 January 1982

W. John Kalk, Michael C. Kew, Mervyn D. Danilewitz, Frederick Jacks, L. Andre Van Der Walt, Joseph Levin – 1 January 1982 – To determine the prevalence of elevated serum concentrations of thyroxine binding globulin (TBG) in patients with hepatocellular carcinoma (HCC) and the influence of the associated cirrhosis, TBG was measured in 39 patients with HCC, 22 with and 17 without cirrhosis, in 20 patients with cryptogenic macronodular cirrhosis but without HCC, and in 40 matched controls.

Vernon Campbell, Paul D. Greig, Jeff Cranford, Bernard Langer, Melvin Silverman, Laurence M. Blendis – 1 January 1982 – To define the relationship between portal hypertension and renal excretion of salt and water, two acute animal models of portal hypertension were investigated. In both models, it was necessary for systemic and renal hemodynamics to remain unchanged during the creation of portal hypertension so as to eliminate the effects of change in these parameters on renal excretion.

Don P. Jones – 1 January 1982

Bernhard H. Lauterburg, Jerry R. Mitchell – 1 January 1982 – The effect of a toxic dose of acetaminophen on hepatic glutathione turnover was studied in fed and fasted rats. Following the administration of 1 gm per kg of acetaminophen, the fractional rate of glutathione turnover increased from 0.19 to 0.28 hr−1 in fed rats and from 0.43 to 0.50 hr−1 in rats fasted for 48 hr. The increase in the fractional rate of turnover was proportionally much less than the decrease in hepatic glutathione concentration resulting from the toxic dose of acetaminophen.

Michael Manns, Karl‐Hermann Meyer, Zum Büschenfelde – 1 January 1982 – A radioimmunoassay (RIA) was established for the detection of antimitochondrial autoantibodies (AMAs) in patient sera. AMAs were detected by RIA in 12 of 14 patients with primary biliary cirrhosis and in 3 of 29 patients with chronic active hepatitis. AMAs were detected by indirect immunofluorescence in all sera positive by RIA.

Michael A. Dunn, Refaat Kamel – 1 November 1981