Alan D. Attie, Ray C. Pittman, Daniel Steinberg – 1 March 1982

Stewart Sell, Hyam L. Leffert – 1 January 1982 – Analysis of liver from rats exposed to chemical hepatocarcinogens has led to a model that postulates sequential premalignant changes, culminating in hepatoma formation from neoplastic nodules. Several experimental protocols devised during the last quarter century have focused upon this lineage model. But proof that neoplastic nodules are the definitive premalignant lesions has not been achieved.

Raymond S. Koff – 1 January 1982

Humberto Reyes – 1 January 1982

1 January 1982

Joseph L. Melnick – 1 January 1982

Lorne E. Rotstein, Leonard Makowka, George Lee, Emmanuel Farber – 1 January 1982 – The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules.

1 January 1982

1 January 1982

Samuel W. French, Isao Kondo, Tetsuya Irie, Thomas J. Ihrig, Nancy Benson, Robert Munn – 1 January 1982 – Rat livers perfused with 0.5% Triton X‐100 for 15 to 90 min followed by 1% sodium dodecyl sulfate for 30 min were studied by electron microscopy and polyaerylamide gel electrophoresis. After 15 min of perfusion, a rich network of intermediate filaments and microtubules was visualized in the cytoplasm of hepatocytes. Using stereopairs, branching was visualized. Connections of filaments were noted with nuclei, centrioles, microtubules, vesicles, and rough endoplasmic reticulum.