H. O. Conn, R. H. Resnick, N. D. Grace, C. E. Atterbury, D. Horst, R. J. Groszmann, P. Gazmuri, R. J. Gusberg, B. Thayer, D. Berk, S. C. Wright, R. Vollman, D. M. Tilson, W. V. McDermott, J. A. Cohen, M. Kerstein, A. L. Toole, J. P. Maselli, S. Razvi, A. Ishihara, H. Stern, C. Trey, E. T. O'hara, W. Widrich, H. Aisenberg, H. C. Stansel, M.
Z. Reno Vlahcevic, Marc Goldman, Charles C. Schwartz, Jan Gustafsson, Leon Swell – 1 March 1981 – The present report has been directed toward providing additional information on the major defects in the bile acid pathways present in patients with cirrhosis and its relevance to the problem of how bile acid synthesis is regulated in man. An unusual patient with severe liver disease and a completely broken enterohepatic circuit was studied. The synthesis of cholic and chenodeoxycholic acids was examined over a 5‐d period.
Ferruccio Bonino, Bill Hoyer, Eugenie Ford, J. Wai‐Kuo Shih, Robert H. Purcell, John L. Gerin – 1 March 1981 – The hepatitis B virus‐associated delta antigen was detected in the serum of a young female drug addict with acute hepatitis and a previous history of hepatitis B surface antigen carrier. Delta antigen was associated with a 35‐ to 37‐nm subpopulation of hepatitis B surface antigen particles which banded at a density of 1.25 gm per cm3 of CsCl and contained a small RNA of approximately 5.5 × 105 molecular weight.
Hans Popper, James W.‐K. Shih, John L. Gerin, Doris C. Wong, Bill H. Hoyer, William T. London, David L. Sly, Robert H. Purcell – 1 March 1981 – The livers of 33 captive woodchucks were examined histologically in 30 biopsy and 10 autopsy specimens and the findings were correlated with serum determinations for woodchuck hepatitis virus (WHV), surface antigen (WHsAg) and antibody (anti‐WHs), and WHV DNA and DNA polymerase.
Darrell Doyle, Anh V. Le – 1 March 1981
Alfred M. Prince – 1 January 1981
Anasticio M. Hoyumpa, Rashmi Patwardhan, Michael Maples, Paul V. Desmond, Raymond F. Johnson, Alicia P. Sinclair, Steven Schenker – 1 January 1981 – The disposition of chlordiazepoxide (Librium®) and diazepam (Valium®), compounds which are initially degraded by oxidative processes, differs from that of oxazepam (Serax®) and lorazepam (Ativan®), drugs which are inactivated by conjugation with glucuronic acid. Liver disease and cimetidine impair the elimination of the former agents, but not the latter two benzodiazepines.
David A. Shafritz, Michael C. Kew – 1 January 1981 – DNA extracts from hepatocellular carcinomas of 13 patients from South Africa were examined for hepatitis B virus (HBV) DNA sequences by molecular hybridization using [32P]‐labeled recombinant, cloned, and purified HBV‐DNA. Eight patients were HBV carriers as demonstrated by the presence of hepatitis B surface antigen (HBsAg) in their serum, and each of these patients had HBV‐DNA sequences in hepatocellular carcinoma tissue. Five patients who were not HBsAg carriers, did not have HBV‐DNA in their tumors.
Michael A. Dunn, Sam Seifter, Penelope K. Hait – 1 January 1981 – Proline, a critical substrate for collagen synthesis, is increased in liver undergoing fibrosis. In mice with schistosomiasis, the incorporation of proline into collagen occurs within liver granulomas. To study the interaction of liver cells and granulomas in the development of fibrosis, we assayed the enzymes that catalyze the formation and degradation of proline in isolated granulomas and liver.
Angelos Afroudakis, Neil Kaplowitz – 1 January 1981 – The liver histopathology in 40 liver biopsies from 24 patients with verified chronic common bile duct stenosis due to chronic alcoholic pancreatitis has been reviewed code‐blinded. This represents an 8% prevalence of this complication in approximately 300 patients with alcoholic pancreatitis screened biochemically for alkaline phosphatase >two‐fold for >1 month. The majority were anicteric with no symptoms other than from acute exacerbations of chronic pancreatitis.