Hepatic and extrahepatic glucuronidation of lorazepam in the dog

John F. Gerkens, Paul V. Desmond, Steven Schenker, Robert A. Branch – 1 July 1981 – The pharmacokinetic disposition of lorazepam was investigated in sham‐operated anesthetized dogs, dogs with hepatic devascularization, and dogs with total splanchnic devascularization following i.v. administration of 0.3 mg per kg of the drug. In sham‐operated dogs, lorazepam distribution was extensive (100 ± 15.2 liters) and clearance approximated expected liver blood flow (971 ± 91 ml per min). Lorazepam glucuronide levels in plasma rose rapidly in the first hour and reached a plateau by 5 hr.

Muscle protein breakdown in liver cirrhosis and the role of altered carbohydrate metabolism

Giulio Marchesini, Marco Zoli, Angela Angiolini, Cristina Dondi, Francesco B. Bianchi, Emilio Pisi – 1 July 1981 – The rates of muscle protein breakdown, as estimated by the urinary excretion of 3‐methylhistidine, were assessed in 30 cirrhotics and 15 controls on a strictly controlled diet. 3‐Methylhistidine excretion was increased in cirrhotics irrespective of the etiology of the disease, and correlated with basal glucagon levels and with the insulin/glucagon ratio.

δ antigen in hepatitis B: Immunohistology of frozen and paraffin‐embedded liver biopsies and relation to HBV infection

Elisabeth St. Öcklin, Fred Gudat, Gunthild Krey, Ursula Dürmüller, Markus Gasser, Martin Schmid, Georg Stalder, Leonardo Bianchi – 1 May 1981 – The finding that the recently described hepatitis B (HB)‐associated delta antigen (δ Ag) is preserved in pronase‐treated, formalin‐fixed paraffin sections allowed a combined prospective and retrospective immunohistological study of its occurrence in 571 liver biopsies.

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