Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line

Haizhen Zhu, Hongshan Zhao, Christin D. Collins, Sarah E. Eckenrode, Qingguo Run, Richard A. McIndoe, James M. Crawford, David R. Nelson, Jin‐Xiong She, Chen Liu – 30 December 2003 – Interferon alfa (IFN‐α)‐based treatment is the only therapeutic option for chronic hepatitis C viral infection. However, the molecular mechanisms of IFN‐α antiviral activity are not completely understood. The recent development of an HCV replicon cell culture system provides a feasible experimental model to investigate the molecular details of IFN‐induced direct antiviral activity in hepatocytes.

Repopulation of rat liver by fetal hepatoblasts and adult hepatocytes transduced ex vivo with lentiviral vectors

Michael Oertel, Richard Rosencrantz, Yuan‐Qing Chen, Prashanthi N. Thota, Jaswinderpal S. Sandhu, Mariana D. Dabeva, Annmarie L. Pacchia, Martin E. Adelson, Joseph P. Dougherty, David A. Shafritz – 30 December 2003 – Recent studies have shown that nondividing primary cells, such as hepatocytes, can be efficiently transduced in vitro by human immunodeficiency virus‐based lentivirus vectors. Other studies have reported that, under certain conditions, the liver can be repopulated with transplanted hepatocytes.

Toll‐Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells

Yong‐Han Paik, Robert F. Schwabe, Ramón Bataller, Maria P. Russo, Christian Jobin, David A. Brenner – 30 December 2003 – Bacterial lipopolysaccharide (LPS) stimulates Kupffer cells and participates in the pathogenesis of alcohol‐induced liver injury. However, it is unknown whether LPS directly affects hepatic stellate cells (HSCs), the main fibrogenic cell type in the injured liver. This study characterizes LPS‐induced signal transduction and proinflammatory gene expression in activated human HSCs.

Cell adhesion regulates platelet‐derived growth factor–induced MAP kinase and PI‐3 kinase activation in stellate cells

Vinicio Carloni, Raffaella M. S. DeFranco, Alessandra Caligiuri, Alessandra Gentilini, Silvia Cappadona Sciammetta, Elisabetta Baldi, Benedetta Lottini, Paolo Gentilini, Massimo Pinzani – 30 December 2003 – The biologic effects of growth factors are dependent on cell adhesion, and a cross talk occurs between growth factors and adhesion complexes. The aim of the present study was to evaluate the influence of cell adhesion on the major intracellular signaling pathways elicited by platelet‐derived growth factor (PDGF) in hepatic stellate cells (HSC).

Effects of noradrenalin and albumin in patients with type I hepatorenal syndrome: A pilot study

Christophe Duvoux, David Zanditenas, Christophe Hézode, Anthony Chauvat, Jean‐Luc Monin, Françoise Roudot‐Thoraval, Ariane Mallat, Daniel Dhumeaux – 30 December 2003 – Treatment of hepatorenal syndromes (HRSs) is currently based on vasopressin analogs. The aim of this pilot study was to evaluate the efficacy and safety of noradrenalin (NA) in the treatment of type 1 HRS.

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