Higher frequency of HCV in patients with non‐Hodgkin lymphoma: Is it enough to suggest an association with B‐cell NHL?
Emilio Iannitto, Vincenzo Barbera, Rocco Gambino, Emanuele Ammatuna, Giuseppe Montalto, Rosa Di Stefano – 30 December 2003
Applicability of real‐time PCR combined with melting curve analysis for the study of hepatitis B virus genome mutations
Francisco Rodriguez‐Frias, Rosendo Jardi, Maria Buti, Rafael Esteban – 30 December 2003
Mechanisms of hepatocyte protection against hypoxic injury by atrial natriuretic peptide
Rita Carini, Maria Grazia De Cesaris, Roberta Splendore, Cinzia Domenicotti, Maria Paola Nitti, Maria Adelaide Pronzato, Emanuele Albano – 30 December 2003 – Atrial natriuretic peptide (ANP) reduces ischemia and/or reperfusion damage in several organs, but the mechanisms involved are largely unknown. We used freshly isolated rat hepatocytes to investigate the mechanisms by which ANP enhances hepatocyte resistance to hypoxia.
Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement
Agustín Albillos, Antonio de la Hera, Mónica González, Jose‐Luis Moya, Jose‐Luis Calleja, Jorge Monserrat, Luis Ruiz‐del‐Arbol, Melchor Alvarez‐Mon – 30 December 2003 – Intestinal bacterial overgrowth and translocation, both common in cirrhosis with ascites, may lead to the activation of monocytes and lymphocytes, increased levels of proinflammatory cytokines, and enhanced synthesis of nitric oxide present in cirrhosis. Bacterial endotoxin promotes the synthesis of lipopolysaccharide (LPS)‐binding protein (LBP), and forms a LPS‐LBP complex that binds to CD14.
Induction of cellular resistance against Kupffer cell–derived oxidant stress: A novel concept of hepatoprotection by ischemic preconditioning
Rolf J. Schauer, Alexander L. Gerbes, Daniel Vonier, Mark op den Winkel, Peter Fraunberger, Manfred Bilzer – 30 December 2003 – Ischemic preconditioning (IP) triggers protection of the liver from prolonged subsequent ischemia. However, the underlying protective mechanisms are largely unknown. We investigated whether and how IP protects the liver against reperfusion injury caused by Kupffer cell (KC)‐derived oxidants.
Endogenous IL‐13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury
Atsushi Kato, Tomohisa Okaya, Alex B. Lentsch – 30 December 2003 – Hepatic ischemia/reperfusion injury involves a complex inflammatory cascade resulting in neutrophil‐mediated injury of hepatocytes. Previous studies from our laboratory have established that exogenous administration of the anti‐inflammatory cytokines interleukin 10 (IL‐10) and IL‐13 can ameliorate the inflammatory response and significantly reduce hepatocellular injury.
Antiviral therapy in HBe‐Ag–positive hepatitis B with normal aminotransferase levels
- Read more about Antiviral therapy in HBe‐Ag–positive hepatitis B with normal aminotransferase levels
Andreas Geier, Christoph G. Dietrich, Carsten Gartung – 30 December 2003
Reduced hepatic tumor incidence in cyclin G1‐deficient mice
Michael Rugaard Jensen, Valentina M. Factor, Anna Fantozzi, Kristian Helin, Chang‐Goo Huh, Snorri S. Thorgeirsson – 30 December 2003 – Cyclin G1 is a transcriptional target of the tumor suppressor p53, and its expression is increased after DNA damage. Recent data show that cyclin G1 can regulate the levels of p53 by a mechanism that involves dephosphorylation of Mdm2 by protein phosphatase 2A. To understand the biologic role of cyclin G1, we have generated cyclin G1‐deficient mice.
Prediction of histology in hepatitis C
Claudio Puoti, Roberto Castellacci, Fabrizio Montagnese, Lia Bellis, Federica Festuccia, Paolo Corvisieri – 30 December 2003
Randomized trial comparing albumin and saline in the prevention of paracentesis‐induced circulatory dysfunction in cirrhotic patients with ascites
Javier Sola‐Vera, Josep Miñana, Elena Ricart, Montserrat Planella, Begoña González, Xavier Torras, Jose Rodríguez, José Such, Sonia Pascual, Germán Soriano, Miguel Pérez‐Mateo, Carlos Guarner – 30 December 2003 – Paracentesis‐induced circulatory dysfunction (PICD) is a recently described complication that can be prevented with the administration of plasma expanders. The aim of this study was to compare the efficacy of saline versus albumin in the prevention of PICD. Patients were randomized to receive albumin or saline after total paracentesis.