Ziad Hassoun, Vijay Shah, Christine M. Lohse, V. Shane Pankratz, Lydia M. Petrovic – 22 March 2004 – Several studies have linked centrilobular necrosis (CN) to acute cellular rejection (ACR) following liver transplantation. However, it may be difficult to establish the diagnosis of ACR when the classic portal features are absent. The aim of the present study was to identify specific features that would help to recognize ACR in biopsies with CN. One hundred and forty liver biopsies with CN were identified from 97 patients who underwent liver transplantation.

John Michael Tredger, Nigel William Brown, Jemimah Adams, Chris Elton Gonde, Anil Dhawan, Mohamed Rela, Nigel Heaton – 22 March 2004 – Predose plasma mycophenolic acid (MPA) concentrations measured with a semi‐automated enzyme‐multiplied immunoassay were related to adverse events (e.g., rejection, leukopenia, infection), drug dose, and clinical status in 147 adult and 63 pediatric liver allograft recipients receiving adjunctive immunosuppression with mycophenolate mofetil (MMF).

22 March 2004

Kellee Slater, Thomas E. Bak, Igal Kam, Michael E. Wachs – 22 March 2004 – Liver transplantation is now an acceptable treatment for small hepatocellular carcinomas in the setting of cirrhosis. Larger tumors in cirrhotic livers and unresectable tumors in noncirrhotic livers (including fibrolamellar hepatocellular carcinomas) may also be indications for transplantation. With the limited number of cadaver grafts available, living donor liver transplant is becoming an option for some of these patients.

J. Michael Millis – 22 March 2004

Anna Serafín, Joan Roselló‐Catafau, Neus Prats, Emilio Gelpí, Joan Rodés, Carmen Peralta – 27 February 2004 – The present study evaluates the effect of ischemic preconditioning on interleukin‐1 (IL‐1) and interleukin‐10 (IL‐10) generation following hepatic ischemia/reperfusion (I/R) in normal and steatotic livers as well as the role of nitric oxide (NO) in this process. Increased IL‐1β and IL‐10 levels were observed in normal livers after I/R. Steatotic livers showed higher IL‐1β levels than normal livers, and IL‐10 at control levels.

Stephen H. Caldwell, Charissa Chang, B. Gail Macik – 27 February 2004 – The management of coagulopathy in patients with acute and chronic liver disease has undergone little change in many years despite advances in our understanding of the pathogenesis of this problem. In general, deficiency of clotting factors as a result of poor hepatic synthetic function accounts for most of the coagulopathy.

Anna S.F. Lok, Brian J. McMahon – 27 February 2004

Nicolas André, Bertrand Roquelaure, Isabelle Thuret, Marianne Ziol, Frédéric Rieux‐Laucat, Françoise Le Deist – 27 February 2004

Juan Rodés – 27 February 2004