Total volume paracentesis decreases variceal pressure, size, and variceal wall tension in cirrhotic patients

D. Kravetz, G. Romero, J. Argonz, M. Guevara, A. Suarez, R. Abecasis, M. Bildozola, J. Valero, R. Terg – 30 December 2003 – It has been suggested that ascites is a risk factor for variceal bleeding in cirrhotic patients. However, no data of total volume paracentesis (TVP) effects on variceal hemodynamics has yet been published. The aim of this study was to investigate the effects of TVP on variceal pressure, size, and tension in cirrhotic patients. Before sclerotherapy, 18 cirrhotic patients with grade II esophageal varices were studied.

The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis

P. C. Adams, Y. Deugnier, R. Moirand, P. Brissot – 30 December 2003 – The aim of this study was to investigate the relationship between iron overload, age, and clinical symptoms in genetic hemochromatosis. The relationship was studied between clinical symptoms and liver iron concentration, serum ferritin, and iron removed in a retrospective study of 410 homozygotes diagnosed using strict criteria. No significant relationship was found between liver iron concentration, iron removed by venesection, and serum ferritin level with age.

Expression of the rat liver Na+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion

C Gartung, S Schuele, S F Schlosser, J L Boyer – 30 December 2003 – Expression and function of the hepatic Na+/taurocholate cotransporter (ntcp) are down‐regulated in several models of experimental cholestasis. To test whether retention and/or depletion of biliary constituents are involved in ntcp regulation, ntcp expression was quantified in several animal models with altered levels of these constituents.

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