The mechanism of biliary excretion of α1‐acid glycoprotein in the rat: Evidence for a molecular weight‐dependent, nonreceptor‐mediated pathway

Peter Thomas, Carol A. Toth, Norman Zamcheck – 1 November 1982 – The transport of human α1‐acid glycoprotein from the circulation to the bile has been studied in the rat. Biliary excretion was proportional to the i.v. injected dose, and the percentage excreted remained constant. The amount excreted in the bile (over 4 hr) was inversely related to the rate of hepatic (hepatocyte) uptake and the galactose receptor which is specific for asialo glycoproteins was not involved.

Pigment gallstone disease: Summary of the national institutes of health—international workshop

Bruce W. Trotman, Roger D. Soloway – 1 November 1982 – This report summarizes the proceedings of the first National Institutes of Health—International Workshop on Pigment Gallstone Disease. The meeting held at the University of Pennsylvania in May, 1981 consisted of eight sessions in which the following aspects of pigment gallstone disease were discussed: (a) classification; (b) epidemiology; (c) radiographic assessment; (d) gallstone composition; (e) composition of bile; (f) pathogenesis; (g) animal models, genetics, and computer analysis, and (h) medical treatment.

Kinetics of 64copper in primary biliary cirrhosis

A. Roelof Janssens, Cornelis J. A. Van Den Hamer – 1 November 1982 – To assess the pathogenetic mechanisms involved in the accumulation of copper in primary biliary cirrhosis (PBC), the kinetics of 64Copper (64Cu) were studied in 6 healthy volunteers, 3 patients with PBC (Stages I to III) and a normal liver copper, and 7 patients with PBC (Stages II to IV) and a high liver copper. The kinetics of oral and i.v. administered 64Cu in patients with a normal liver copper were similar to those in controls.

Viral infections of humans. Epidemiology and control. Edited by Alfred S. Evans, professor of epidemiology and public health, Yale University School of Public Health. Second edition, completely revised and expanded. xxxvi + 720 pp. New York and London: Pl

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