<div><p><strong><b>Background:</strong> </b>Heterogeneity among patients with acute-on-chronic liver failure (ACLF) confer variable outcomes (mortality-range: 0-100%). While prognostic scores capture the known associations, machine learning (ML) can identify the intricate hidden patterns between patient characteristics without any explicit hypothesis or labelling that remain unexplored in ACLF. We employed ML to explore, describe, and predict unknown clusters in ACLF patients.</p>
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<div><p><b>Background:</p> </b><div><p><span lang="EN-US">Obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD) are becoming increasingly prevalent. Bariatric surgery, combining weight loss with metabolic improvements, may represent an effective treatment for these disease entities in obese patients with single anastomosis doudeno-ileal bypass with sleeve gastrectomy (SADI-S) representing a novel bariatric procedure.

<div><p><strong><b>Background:</strong> </b><strong> </strong>Emergency admissions related to chronic liver failure (CLF) are common, expensive and associated with frequent readmission. There are no multicenter randomized controlled trials (RCT) investigating models to reduce liver-related emergency admissions (LREA).

<div><p><b>Background:</p> </b><p>Alcohol related harms to adolescents and young adults (AYAs) are on the rise and a priority group for identification and treatment to prevent progression of alcohol-associated liver disease (ALD). Females are at higher risk of developing ALD compared to males secondary to biologic and social-cultural factors. However, whether this sex difference persists after an episode of acute alcoholic hepatitis (AH) is unknown.

<div><p><b>Background:</p> </b><p>Statins reduce the risk of hepatic fibrosis in patients with chronic liver diseases. Since age, sex, and menopausal status modulate NAFLD pathogenesis and fibrosis risk, the effects of statins on hepatic fibrosis may vary by age and sex. We aimed to assess age-/sex-disparities in the association between statin use and the incidence of cirrhosis in patients with NAFLD.</p>

<div><p><b>Background:</p> </b><p>Newborn Screening (NBS) is successful in identifying infants with fatal but treatable disorders enabling early intervention with favorable outcomes. Unfortunately, many congenital disorders in particular Wilson disease do not feature specific metabolic biomarkers nor analytical methods suitable for NBS even where highly effective preemptive treatments are available.

<div><p><b>Background: </b>Statins may very rarely cause drug induced liver injury (DILI) but its pathogenesis is not well understood. Genetic factors may play a role in the pathogenesis of liver injury due to selected agents. In this study, we investigated genetic factors associated with statin DILI through a genome wide association study (GWAS).</p>

<div><p><b>Background:</p> </b><p><em>PNPLA3</em> rs738409 polymorphism, obesity, and type 2 diabetes mellitus (T2DM) are strongly associated with non-alcoholic fatty liver disease (NAFLD) and its severity in children. Whether <em>PNPLA3</em> rs738409-related predisposition to NAFLD severity is influenced by obesity and T2DM in children with NAFLD is not known.

<div><p><b>Background:<span> </b>Pollution from plastics is an increasing health threat. Microplastics are small plastic pieces, which are formed by direct synthesis for industrial or consumer applications as well as by environmental plastic degradation. As plastic degradation is increased by UV light and “weathering”, global warming has increased environmental microplastics.

<div><p><b>Background: </b>The liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing the accumulation of fibrotic tissue and leading to end-stage liver disease. Enhancing the endogenous regenerative capacity by targeting regeneration breaks is a novel therapeutic approach. We set up an in vivo functional genetic screen to identify such regeneration breaks. Integrin Alpha FG-GAP Repeat Containing 1 (ITFG1) was one of the top hits.