Sexual, reproductive, and cultural factors profoundly impact liver health, yet these dimensions are often overlooked in hepatology care. This program explores the intersection of sexual, reproductive, and liver health in a diverse population, including people with chronic liver disease, HIV, and those who identify as LGBTQ+. Presenters provide insight and suggestions to offer culturally sensitive hepatology care with the goal of empowering clinicians to deliver inclusive, patient-centered care, improving outcomes and equity in liver health across diverse populations. Presentation topics include: (1) oral contraceptive use and pregnancy counseling, including infertility treatment and in vitro fertilization in patients with chronic liver disease and post liver transplantation; (2) common reproductive and liver issues for LGBTQ+ patients, including the hepatologic effects of gender affirming hormone therapy, use of HIV pre-exposure prophylaxis in people with chronic liver diseases, and transplant access; (3) the increasing prevalence of MASLD in people living with HIV (PWH)—which also disproportionally affects the LGBTQ+ and other marginalized populations—exploring unique risk factors, pathophysiology, and management strategies; and (4) culturally sensitive approaches for liver health counseling and practical guidance for specialists and community practitioners to address obstacles faced by LGBTQ+, PWH, and other marginalized populations, especially under current climates.