This session explores the cellular and molecular drivers of cholestatic liver disease and emerging therapeutic strategies utilizing biliary gene therapy. Presentations examine the impact of impairments in biliary transport and signaling in promoting cholestatic injury, inflammation, and fibrosis.

Mobin Ibne Mokbul, M.D. is a Research Fellow in Gastroenterology and Hepatology at Mayo Clinic. His research focuses on translational hepatology, including cholestatic liver diseases, primary sclerosing cholangitis, liver transplantation, normothermic machine perfusion, and RNA therapeutics. He is dedicated in investigating the role of neutrophils in cholestatic liver disease.

Dr. Amar Deep is a medical researcher with extensive experience in clinical and laboratory-based research, particularly in hepatology and viral hepatitis, with a focus on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cirrhosis. His doctoral research, titled "Hepatitis C Related Liver Cirrhosis—A Comprehensive Study," explored the epidemiology, risk factors, and metabolic alterations associated with the progression of chronic hepatitis C to liver cirrhosis.

My mission as a hepatologist at Christian Medical College, Vellore is to provide compassionate, high-quality care that is accessible to all. Specialized expertise lies in treating complex liver conditions, including alcohol-related liver disease and acute-on-chronic liver failure, with a particular focus on plasma exchange. Research interests extend to improving patient outcomes for hepatocellular carcinoma, leveraging artificial intelligence for disease prognostication, and advancing the field of endohepatology and Transplant Hepatology.

I am a Postdoctoral Scientist at Cedars-Sinai Medical Center in Los Angeles, California. My research aims to elucidate the molecular mechanisms driving alcohol-associated liver disease and identify potential molecular targets for therapeutic intervention.

Maria Stepanova, PhD, is a Director of Statistical Services at the Center for Outcomes Research in Liver Diseases (COR-LD), Washington, DC.