Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis

Constantine J. Karvellas, R. Todd Stravitz, Holly Battenhouse, William M. Lee, Michael L. Schilsky, for the US Acute Liver Failure Study Group – 11 October 2014 – The benefit of therapeutic hypothermia (TH) in acute liver failure (ALF) has not been previously demonstrated in a controlled fashion. This study sought to determine the impact of TH on 21‐day survival and complications in ALF patients at high risk for cerebral edema. This was a retrospective cohort study of ALF patients in the US Acute Liver Failure Study Group with grade III or IV hepatic encephalopathy.

Rho‐kinase inhibitor targeting the liver prevents ischemia/reperfusion injury in the steatotic liver without major systemic adversity in rats

Shintaro Kuroda, Hirotaka Tashiro, Yasuhiro Kimura, Kaori Hirata, Misaki Tsutada, Yoshihiro Mikuriya, Tsuyoshi Kobayashi, Hironobu Amano, Yuka Tanaka, Hideki Ohdan – 11 October 2014 – Rho‐kinase (ROCK) inhibitors improve liver blood flow after ischemia/reperfusion (IR) injury, especially in the setting of steatosis, by decreasing the resistance of intrahepatic microcirculation through hepatic stellate cell (HSC) relaxation. However, the systemic administration of ROCK inhibitors causes severe hypotension; therefore, liver‐specific ROCK inhibition is required.

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

Silvia Sookoian, Gustavo O. Castaño, Romina Scian, Pablo Mallardi, Tomas Fernández Gianotti, Adriana L. Burgueño, Julio San Martino, Carlos J. Pirola – 10 October 2014 – We explored the role of transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 C/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and disease severity. A total of 361 individuals (135 control subjects and 226 patients with histologically proven NAFLD) were included in a sample with 97% power for the additive genetic model.

Preoperative simulation with a 3‐dimensional printed solid model for one‐step reconstruction of multiple hepatic veins during living donor liver transplantation

Zhassulan Baimakhanov, Akihiko Soyama, Mitsuhisa Takatsuki, Masaaki Hidaka, Takanori Hirayama, Ayaka Kinoshita, Koji Natsuda, Tamotsu Kuroki, Susumu Eguchi – 10 October 2014

Vasculobiliary complications following adult right lobe split liver transplantation from the perspective of reconstruction techniques

Moustafa Mabrouk Mourad, Christos Liossis, Senthil Kumar, Bridget K. Gunson, Hynek Mergental, John Isaac, Simon R. Bramhall, Paolo Muiesan, Darius F. Mirza, M. Thamara P. R. Perera – 10 October 2014 – Split liver transplantation (SLT) compensates for the organ shortage and provides an alternative solution for recipients disadvantaged by a smaller body size.

Interleukin‐1β/Iinterleukin‐1 receptor‐associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis

Bo Su, Tao Luo, Junjie Zhu, Jing Fu, Xiaofang Zhao, Lei Chen, Huilu Zhang, Yibin Ren, Lexing Yu, Xiaojun Yang, Mengchao Wu, Gensheng Feng, Shao Li, Yao Chen, Hongyang Wang – 7 October 2014 – Hepatocellular carcinoma (HCC) is a prototype of inflammation‐associated cancer. Oncoprotein Gankyrin, which mostly increases in HCC, plays a critical role in HCC development and metastasis. However, the exact mechanism of Gankyrin up‐regulation in HCC remains unclear.

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