Retinoic acid‐related orphan receptor alpha reprograms glucose metabolism in glutamine‐deficient hepatoma cells

Jun‐Kyu Byun, Yeon‐Kyung Choi, Yu Na Kang, Byoung Kuk Jang, Koo Jeong Kang, Yong Hyun Jeon, Ho‐Won Lee, Jae‐Han Jeon, Seung‐Hoi Koo, Won‐Il Jeong, Robert A. Harris, In‐Kyu Lee, Keun‐Gyu Park – 25 October 2014 – The metabolism of glutamine and glucose is recognized as a promising therapeutic target for the treatment of cancer; however, targeted molecules that mediate glutamine and glucose metabolism in cancer cells have not been addressed.

Crucial roles of mixed‐lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice

Dae‐Hwan Kim, Jennifer Chiyeon Rhee, Sujeong Yeo, Rongkun Shen, Soo‐Kyung Lee, Jae W. Lee, Seunghee Lee – 25 October 2014 – The histone H3‐lysine‐4 methyltransferase mixed‐lineage leukemia 3 (MLL3) and its closest homolog, MLL4 (aka KMT2D), belong to two homologous transcriptional coactivator complexes, named MLL3 and MLL4 complexes, respectively. MLL3 plays crucial roles in multiple metabolic processes. However, the physiological roles of MLL4 in metabolism and the relationship between MLL3 and MLL4 in metabolic gene regulation are unclear.

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